Core Capability for Chemistry Research in Southampton

南安普敦化学研究的核心能力

• 批准号: EP/K039466/1
• 负责人: Richard Brown
• 金额: $ 115.17万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK039466%2F1
• 关键词: Core; Capability; Chemistry; Research; Southampton

The overall aim of this application is to modernise and enhance capability of core multi-user instrumentation in Southampton Chemistry to secure the underpinning of a wide range of current and future research projects in Chemistry, and associated disciplines, in EPSRC priority areas. The ability to design, synthesis and characterise molecular species lies at the heart of chemistry. Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS) are two of the key techniques used very widely across organic and inorganic chemistry for the characterisation of small and large molecules and assemblies, and for the identification of the individual constituents present in complex mixtures. They are very powerful techniques that are used on a daily basis by most researchers working in these disciplines. Key elements of this application include: (i) replacing two NMR spectrometers with new, superior instruments to give increased capacity, capability and resilience to the core open access NMR provision at Southampton; (ii) replacing old MS systems with new instruments that will give fast throughput, improved quality results, and allow structural elucidation of compounds unsuitable for NMR spectroscopy. The very high sensitivity of the new MS systems will also be really beneficial for identification of very low level but potentially important impurities, for example those formed during the decay of radio-tracer species used in medical imaging.Scanning Electronic Microscopy (SEM) is an important analytical technique in materials science, which gives highly magnified images of the morphology of solids, including powders, microcrystals, thin films and nanoparticles. By using specific probes attached to the SEM, quantitative information concerning the elements present, including low level impurities that might compromise the properties of the materials, can be obtained. This application also seeks to upgrade an existing SEM instrument through replacement of its work station and operating system, and will ensure that the ability to obtain these types of information from new materials produced in Southampton Chemistry is maintained in the future.Southampton Chemistry are committed to obtain maximum value from the capital equipment provided under the grant and have mechanisms enabling external user, including companies and academics, to use the facilities to support their research activities.

该应用程序的总体目标是现代化和提高核心多用户仪器在南安普顿化学的能力，以确保广泛的当前和未来的化学研究项目的基础，以及相关学科，在EPSRC优先领域。设计、合成和修饰分子种类的能力是化学的核心。核磁共振（NMR）光谱和质谱（MS）是有机和无机化学中广泛使用的两种关键技术，用于表征小分子和大分子以及组装体，并用于识别复杂混合物中存在的单个组分。它们是非常强大的技术，在这些学科中工作的大多数研究人员每天都在使用。该应用的关键要素包括：（i）用新的上级仪器替换两台NMR光谱仪，以提高南安普顿核心开放获取NMR的容量、能力和弹性;（ii）用新仪器替换旧MS系统，以提供快速吞吐量、提高质量的结果，并允许对不适合NMR光谱的化合物进行结构解析。新MS系统的极高灵敏度也将真正有益于识别非常低水平但潜在重要的杂质，例如在医学成像中使用的放射性示踪剂物质衰变期间形成的杂质。扫描电子显微镜（SEM）是材料科学中的重要分析技术，其给出固体形态的高度放大图像，包括粉末、微晶、薄膜和纳米颗粒。通过使用附着在SEM上的特定探针，可以获得关于存在的元素的定量信息，包括可能损害材料性能的低水平杂质。该申请还旨在通过更换其工作站和操作系统来升级现有的SEM仪器，并将确保将来能够从南安普顿化学生产的新材料中获得这些类型的信息。南安普顿化学致力于从赠款下提供的资本设备中获得最大价值，并具有使外部用户，包括公司和学术界，使用这些设施来支持他们的研究活动。

项目成果

A Corey-Seebach Macrocyclisation Strategy for the Synthesis of Riccardin C and an Unnatural Macrocyclic Bis(bibenzyl) Analogue

• DOI: 10.1002/ejoc.201601179
• 发表时间: 2016-12-01
• 期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 2.8
• 作者: Almalki, Faisal A.;Harrowven, David C.
• 通讯作者: Harrowven, David C.

A Two-Directional Synthesis of (+)-ß-Isosparteine.

( )-isosparteine 的双向合成。

• DOI: 10.1021/acs.orglett.7b01475
• 发表时间: 2017
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Al-Saffar FM

A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans.

• DOI: 10.1039/d1cc02097h
• 发表时间: 2021-05
• 期刊: Chemical communications
• 影响因子: 4.9
• 作者: Ryan M Bennett;Wei Sun;Dharyl C Wilson;M. Light;D. Harrowven

Printable biflourene based ultra-violet (UV) organic light-emitting electrochemical cells (OLECs) with improved device performance

• DOI: 10.1016/j.orgel.2022.106513
• 发表时间: 2022-04
• 期刊: Organic Electronics
• 影响因子: 3.2
• 作者: Sasikumar Arumugam;Yi Li;James E. Pearce;Katie L. Court;Giacomo M. Piana;E. Jackman;Oliver J. Ward;M. Charlton;J. Tudor;D. Harrowven;S. Beeby

Total synthesis of polymorphatin A, a macrocyclic bisbibenzyl with boat configured arenes

多晶型A（一种具有船型芳烃的大环双联苄）的全合成

• DOI: 10.1016/j.tet.2020.131521
• 发表时间: 2020
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Almalki F