EARLY PREGNANCY LOSS AMONG FEMALE OFFICE WORKERS

我们建议进行一项前瞻性流行病学研究，以期在早期 8000名女性上班族中的怀孕损失。这个 目标是(1)确定早期妊娠流失率 新开发的高灵敏免疫放射测定法 尿中人绒毛膜促性腺激素(HCG)；和(2)测定， 使用这一检测方法，早期妊娠丢失是否与 吸烟、饮酒或观看视频展示 终端(VDT)。 早期亚临床妊娠丢失的流行病学不是很好 已定义。生活方式和有毒环境暴露都可能 对其病因学有贡献。可能是不明原因造成的 不孕不育。之前在高选择人群中进行的研究已经 证明了免疫放射人绒毛膜促性腺激素检测作为 目的探讨早期妊娠丢失的客观指标。这个分子探测器有 然而，没有被用来评估亚临床的流行病学。 一般人群中的早孕丢失。 在最初的横断面调查中，我们将描述 女性上班族，识别有风险的女性 怀孕，并收集有关潜在风险的信息 早孕丢失的因素。 被确定为有怀孕风险的妇女(性活跃 和不使用节育措施)(估计N=720)将遵循 预期为期一年。每名女性将收集两个尿液 月经开始时的每月样本；怀孕和 通过对这些标本进行hCG检测，将确定妊娠丢失。 每个女性都要完成月度报告，详细说明吸烟、饮酒 消费和VDT使用。与工作相关的压力源(人体工程学和 心理)和可能的电磁辐射暴露 将评估与VDT使用相关的内容。最大似然 将使用Logistic回归对早孕风险进行建模 损失。

We propose to conduct a prospective epidemiologic study of early pregnancy loss in a population of 8,000 women office workers. The goals are (1) to determine rates of early pregnancy loss using a newly developed, highly sensitive, immunoradiometric assay for human chorionic gondotropin (hcG) in urine; and (2) to determine, using this assay, whether early pregnancy loss is associated with cigarette smoking, alcohol consumption or exposure to video display terminals (VDTs). The epidemiology of early, subclinical pregnancy loss is not well defined. Both lifestyle and toxic environmental exposures may contribute to its etiology. It may be unrecognized cause of infertility. Previous studies in highly selected populations have demonstrated the utility of immunoradiometric hCG assay as an objective marker of early pregnancy loss. This molecular probe has not, however, been used to assess the epidemiology of subclinical early pregnancy loss in a general population. In an initial cross-sectional survey, we will characterize the population of women office workers, identify women at risk of becoming pregnant, and collect information on potential risk factors for early pregnancy loss. Women identified as at risk of becoming pregnant (sexually active and not using birth control) (estimated N=720) will be followed prospectively for one year. Each women will collect two urine samples each month at the beginning of menses; pregnancy and pregnancy loss will be established by hCG assay of these specimens. Each women will complete monthly reports detailing smoking, alcohol consumption and VDT use. Both job-related stressors (ergonomic and psychologic) and electromagnetic radiation exposures possibly associated with VDT use will be assessed. Maximum likelihood logistic regression will be used to model risk of early pregnancy loss.