HEMORRHAGIC DISEASES

出血性脑血管病的发病机制、诊断和治疗 提出了防治疾病的建议，重点是以下领域： 膜血小板标志物;免疫学和免疫化学研究： 血小板抗体结合的膜成分及其机制 药物-抗体-血小板相互作用的研究进展 血小板减少症将在分子水平上表征。 可变 血小板表面HLA-A和B标记物的表达及其意义 将探讨血小板输注疗法。 血小板免疫疾病;血小板输注的免疫学方面 治疗：将进行研究以提高敏感性， 血小板抗体检测特异性与血小板测定 相关免疫球蛋白。 以前未描述的关系， 对正常人外周血单个核细胞上酶激活位点特异的温反应性巨球蛋白 血小板在自身免疫性血小板减少性紫癜发病机制中的作用 童年将被定义。 的自然史和对治疗的反应 新生儿同种免疫性血小板减少性紫癜和输血后紫癜 将得到进一步表征。 改善血小板匹配的研究 对于同种免疫的血小板减少症患者，并确定 对血小板输注反应的循环免疫复合物将 进行。 血小板分离和短期保存的最佳条件： 将寻求提高血小板浓缩物质量的方法， 强调使用腺苷酸环化酶抑制剂的意义， 激活血小板的内源性钙激活蛋白酶，和 储存期间的搅拌方式。 白细胞在 将进一步表征血小板保存。 人血小板异质性：生理学意义：血小板异质性的研究 决定人体血小板浮力密度的因素， 浮力密度对血小板年龄的影响，以及人类 血小板在老化过程中将进行。

Studies of the pathogenesis, diagnosis and treatment of hemorrhagic diseases are proposed, with emphasis on the following areas: Membrane platelet markers; immunologic and immunochemical studies: Membrane constitutents to which platelet antibodies bind and the mechanism of drug-antibody-platelet interaction in drug-induced immune thrombocytopenia will be characterized at a molecular level. The variable expression of HLA-A and B markers on platelets and its implications for platelet transfusion therapy will be explored. Immune disorders of platelets; immunologic aspects of platelet transfusion therapy: Studies will be conducted to improve the sensitivity and specificity of platelet antibody detection and measurement of platelet associated immunoglobulins. The relationship of previously undescribed, warm-reactive macroglobulin specific for an enzyme-activated site on normal platelets to the pathogenesis of autoimmune thrombocytopenic purpura of childhood will be defined. The natural history and response to therapy of neonatal alloimmune thrombocytopenic purpura and post-transfusion purpura will be further characterized. Studies to improve matching of platelets for alloimmunized thrombocytopenic patients and to define the importance of circulating immune complexes in the response to platelet transfusions will be conducted. Optimum conditions for isolation and short-term preservation of platelets: Methods to improve the quality of platelet concentrates will be sought with emphasis on the use of inhibitors of adenylate cyclase, the significance of activation of the endogenous, calcium-activated protease of platelets, and the mode of agitation during storage. The importance of leukocytes in platelet preservation will be further characterized. Human platelet heterogeneity: physiologic significance: Studies of the factors that determine buoyant density of human platelets, the relationship of buoyant density to platelet age, and the changes that occur in human platelets during the aging process will be conducted.