EFFECTS OF PRENATAL SONOGRAPHY ON POSTNATAL DEVELOPMENT

这项提案的长期目标是评估 妊娠期超声诊断性成像。尽管它的好处和 诊断超声的优势被广泛欣赏和接受为 一种产前诊断工具，目前尚不清楚诊断超声的使用情况 在怀孕期间对发育中的胎儿没有风险。这种担忧是 最近脉冲多普勒技术的引入增加了对 产前诊断目的。这项技术被用在了第三个 怀孕三个月，超声强度(SPTA)为5至10 倍数大于传统产科连续波多普勒。因为它的 结构和功能的复杂性特别是中枢神经系统 在孕期后期易受毒物侮辱 发展。这项建议的具体目的是评估效果 脉冲多普勒超声的强度与临床应用相当 妊娠晚期胎鼠。由一个笼子组成的五个处理组 对照，一个假对照和三个单独的超声强度 在研究设计中使用。分娩后，每只幼崽 治疗组将通过行为测试组合进行评估，以评估： 1)妊娠结局，2)身体发育和成熟，3)反射和 运动发育，4)感觉功能，5)活动性和反应性水平， 6)学习和记忆能力；7)神经运动功能 系统。这些研究将根据普洛斯的指导方针进行，以确保 适用于以下方面的框架下的数据质量和完整性 接受联邦管理机构(FDA)。这些研究的结果 研究将提供有关超声波的生物效应的信息 怀孕对出生后发育的影响，并使合理估计 超声波对发育中生物体的生物效应和风险。

The longterm objectives of this proposal is to evaluate the safety of diagnostic ultrasound imaging in pregnancy. Although the benefits and advantages of diagnostic ultrasound are widely appreciated and accepted as a prenatal diagnostic tool it is not clear if diagnostic ultrasound usage during pregnancy is free of risk to the developing fetus. This concern is increased by the recent introduction of the pulse Doppler technique for prenatal diagnostic purposes. This technique is used in the third trimester of pregnancy and presents an ultrasound intensity (SPTA) 5 to 10 fold greater than traditional obstetrical CW Doppler. Because of its complexity of structure and function the CNS is recognized as especially susceptible to toxic insults during this later period of prenatal development. The specific aim of this proposal is to evaluate the effects of pulsed Doppler Ultrasound at intensities comparable to clinical use on third trimester fetal rats. Five treatment groups consisting of a cage control, a sham control and three separate ultrasound intensities will be used in the study design. Following parturition the pups from each treatment group will be evaluated by a behavioral test battery to assess: 1) pregnancy outcome, 2) physical growth and maturation, 3) reflex and motor development, 4) sensory function, 5) activity and reactivity levels, 6) learning and memory abilities, and 7) functioning in neuromotor systems. These studies will be conducted under GLP guidelines to assure the quality and integrity of the data under a framework suitable for acceptance to Federal Regulatory Agencies (FDA). The results from these studies will provide information on the bioeffects of ultrasound during pregnancy on postnatal development and enable reasonable estimates of bioeffects and risks of ultrasound on developing organism.