FAT METABOLISM AND EXPERIMENTAL ATHEROSCLEROSIS

将继续研究血浆甘油三酯在 动脉粥样硬化的形成。将研究几种模型：四氧嘧啶糖尿病兔， 肾上腺皮质激素注射，洗涤剂注射。的作用 脂蛋白颗粒大小和组成在液体摄取率和 我们将研究脂肪酸酯的体内水解性。我们也期待着 目的：研究血浆脂质转移活性在高血压病中的潜在作用。 动脉粥样硬化的形成。兔的脂转移活性很高，并且增加 在高胆固醇血症期间，而大鼠很少或没有这种活动 在血浆中。改变血浆脂蛋白组成的方法 将被开发并在体内清除修饰的脂蛋白 与原来的脂蛋白清除量相比。

Research will continue on the role of plasma triglycerides in atherogenesis. Several models will be studied: Alloxan diabetic rabbit, adrenal corticoid administration, detergent injections. The role of lipoprotein particle size and composition in the rate of liquid uptake and in vivo hydrolysis of fatty acid esters will be examined. We also expect to study a potential role of plasma lipid transfer activity in atherogenesis. Lipid transfer activity in rabbits is high and increases during hypercholesterolemia, whereas the rat has little or no such activity in plasma. Methods for altering the composition of plasma lipoproteins will be developed and in vivo clearance of modified lipoproteins will be compared to the original lipoprotein clearance.