EARLY PREGNANCY LOSS AMONG FEMALE OFFICE WORKERS

我们建议进行一项前瞻性的流行病学研究， 8 000名女性办公室工作人员的妊娠损失。 的 目的是（1）使用一种 新开发的高灵敏度免疫放射测定法， 尿中的人绒毛膜促性腺激素（hcG）;和（2）测定， 使用该分析，早期妊娠丢失是否与 吸烟、饮酒或接触视频显示器 终端（VDTs）。 早期亚临床妊娠丢失的流行病学尚不清楚 定义了 生活方式和有毒环境暴露可能 有助于其病因。 它可能是未被认识到的原因， 不孕 先前在高度选择的人群中进行的研究 证明了免疫放射性hCG测定作为一种 早期妊娠丢失的客观标志物。 这个分子探针 然而，尚未用于评估亚临床 一般人群中的早期妊娠丢失。 在最初的横截面调查中，我们将描述 妇女办公室工作人员的人口，确定妇女面临的风险， 怀孕，并收集有关潜在风险的信息 早期妊娠丢失的因素。 被确定为有怀孕风险的妇女（性活跃） 未使用避孕措施）（估计N=720） 预期一年。 每位妇女将收集两次尿液 每月在月经开始时采样;怀孕和 将通过这些标本的hCG测定确定妊娠丢失。 每个女人都要完成每月的报告，详细说明吸烟，饮酒 消费和VDT使用。 与工作相关的压力源（人体工程学和 心理）和电磁辐射暴露可能 与VDT使用有关的问题。 最大似然 将使用逻辑回归对早孕风险进行建模 损失

We propose to conduct a prospective epidemiologic study of early pregnancy loss in a population of 8,000 women office workers. The goals are (1) to determine rates of early pregnancy loss using a newly developed, highly sensitive, immunoradiometric assay for human chorionic gondotropin (hcG) in urine; and (2) to determine, using this assay, whether early pregnancy loss is associated with cigarette smoking, alcohol consumption or exposure to video display terminals (VDTs). The epidemiology of early, subclinical pregnancy loss is not well defined. Both lifestyle and toxic environmental exposures may contribute to its etiology. It may be unrecognized cause of infertility. Previous studies in highly selected populations have demonstrated the utility of immunoradiometric hCG assay as an objective marker of early pregnancy loss. This molecular probe has not, however, been used to assess the epidemiology of subclinical early pregnancy loss in a general population. In an initial cross-sectional survey, we will characterize the population of women office workers, identify women at risk of becoming pregnant, and collect information on potential risk factors for early pregnancy loss. Women identified as at risk of becoming pregnant (sexually active and not using birth control) (estimated N=720) will be followed prospectively for one year. Each women will collect two urine samples each month at the beginning of menses; pregnancy and pregnancy loss will be established by hCG assay of these specimens. Each women will complete monthly reports detailing smoking, alcohol consumption and VDT use. Both job-related stressors (ergonomic and psychologic) and electromagnetic radiation exposures possibly associated with VDT use will be assessed. Maximum likelihood logistic regression will be used to model risk of early pregnancy loss.