ANALGESIA AND SPASM CONTROL AFTER SPINAL CORD INJURY

这项拟议研究的一个基本前提是，在脊椎 脊髓损伤(SCI)患者的感觉运动和知觉能力 神经系统可能被低估了。当前的具体目标 建议是确定感觉运动和知觉反应 阴道/宫颈机械自我刺激(减轻疼痛和 痉挛和性反应的激发)是完整的和 对患有脊髓损伤的女性具有潜在的功能，但尚未被认识到 因此没有得到充分利用。建议的长远目标 研究是为了确定神经系统的实际能力 在SCI之后，以便它们可以被最大程度地利用，从而 丰富生活质量。 这项拟议的研究将确定患有脊髓疾病的女性 损伤(SCI)、阴道和/或宫颈机械自我刺激 在以下方面有效： 1.抑制痉挛。据推测，脊髓损伤的痉挛 会被阴道/宫颈自我刺激所抑制。 2.激活性反应。据推测，性反应 会被宫颈或其他自我刺激所激发。具体来说， 该组件将： A)测试假设，在患有完整脊髓损伤的女性中， T12，宫颈自我刺激可通过 腹下神经，在T11-12进入脊髓。 B)确定机械自我刺激是否 脊髓损伤水平的过敏区产生生理性的 (自主的)与人的感知体验对应的反应 “性高潮。” C)确定阴道自我刺激是否无法唤起 所有水平的脊髓损伤的性反应。 3.抑制神经源性或实验性疼痛。据推测， 脊髓损伤的疼痛将被阴道/宫颈的自我刺激所抑制。 建议的研究利用跨学科的基础研究。 确定术后神经系统功能的方法学 SCI，目标是最大限度地利用这些能力 在开发临床有用的治疗实践方面的程度 丰富生活质量。

A basic premise underlying the proposed research is that after spinal cord injury (SCI), the sensorimotor and perceptual capabilities of the nervous system may be underestimated. The specific aims of the present proposal are to identify sensorimotor and perceptual responses to vaginal/cervical mechanoself-stimulation on (attenuation of pain and spasticity, and elicitation of sexual responses) that are intact and potentially functional in women with SCI, but that have gone unrecognized and consequently under-utilized. The long-term objective of the proposed research is to identify the actual capabilities of the nervous system after SCI so that they can be utilized to the fullest extent and thereby enrich the quality of life. The proposed research will ascertain whether in women with spinal cord injury (SCI), vaginal and/or cervical mechano-self-stimulation is effective in: 1. suppressing spasticity. It is hypothesized that the spasticity of SCI will be suppressed by vaginal/cervical self-stimulation. 2. activating sexual responses. It is hypothesized that sexual response will be elicited by cervical or other self-stimulation. Specifically, this component will: a) test the hypothesis that in women with complete SCI as high as T12, cervical self-stimulation can evoke sexual response via the hypogastric nerve, which enters the spinal cord at T11-12. b) ascertain whether mechano-self-stimulation of the hypersensitive zone at the level of SCI produces physiological (autonomic) responses that correspond to the perceptual experience of "orgasm." c) ascertain whether vaginal self-stimulation fails to evoke sexual response at all levels of SCI. 3. suppressing neurogenic or experimental pain. It is hypothesized that the pain of SCI will be suppressed by vaginal/cervical self-stimulation. The proposed research utilizes interdisciplinary basic research methodology in identifying the capabilities of the nervous system after SCI, with the objective of utilizing those capabilities to the fullest extent in developing clinically useful therapeutic practices toward enriching the quality of life.