REGULATION OF SKIN BLOOD FLOW IN MAN

皮肤循环具有最高的潜在能力之一 区域循环血流量接近8升/分钟。这个 皮肤血流量水平受内部感官控制 体温，皮肤温度，压力感受器，伴随的反射 运动，以及这些来源之间的相互作用。传出控制是 通过肾上腺素能血管收缩系统带来的，一种非 肾上腺素活性血管扩张系统，皮肤的局部温度 以及这些控制要素之间的相互作用。高潮 潜在的血液流动指示皮肤循环和它的 控制很重要，不仅对温度调节，而且对 血压调节，心输出量的分布 运动，和一般的心血管动态平衡。从长远来看 本应用程序的目标是更好地了解这些控制器 以及它们的循环，以及这种控制是如何发挥作用的 体温调节反射、非体温调节反射及其 竞争。对健康的明显重要性是相关的疾病， 这就要求对皮肤循环的控制和它的 充分了解与一般心血管控制的整合，并 感激不尽。下一个资助期的目标通常分为 三个相关的类别，都涉及反射的传出端 控制皮肤循环。这些是(A)一项彻底和 主动血管扩张剂系统反射控制的特异性检查 受压力感受器、皮肤温度和运动的影响。(B)假定的系列 出汗的反射控制与皮肤活动的联系 将通过监测血管扩张系统的活性来进行严格的测试 每次都是在体温调节和非体温调节反射进行的时候。 我们的假设是，类似的反应模式将出现在 体温调节反射，但活跃之间的模式明显不同 运动或压力感受器会伴随血管扩张活性和出汗 条件反射。(C)为了找出身体因素在皮肤中的作用，我们首先 将批判性地审视皮肤血管的命题 对局部热或冷的反应是一种肾上腺素调节的事件， 了解背景血管收缩和血管扩张剂活性在 血管对组织局部加热和冷却的反应。第二，我们 将寻求找出阻力血管的扩张性是否可以 在皮肤血管阻力的变化中起作用 动脉血压升高。

The cutaneous circulation has one of the highest potential capacities for blood flow of the regional circulations, approaching 8 liters/minute. The level of skin blood flow falls under sensory control by internal temperature, skin temperature, baroreceptors, the reflexes accompanying exercise, as well as interactions among these sources. Efferent control is brought about through an adrenergic vasoconstrictor system, a non- adrenergic active vasodilator system, the local temperature of the skin itself and, again, interactions among these elements of control. The high potential blood flow dictates that the cutaneous circulation and its control has importance, not only to temperature regulation, but also to blood pressure regulation, the distribution of the cardiac output during exercise, and to general cardiovascular homeostasis. The long term objectives of this application are to better understand these controllers and their circulation and how that control is brought into play by thermoregulatory reflexes, nonthermoregulatory reflexes and their competition. The obvious importance to health is that related disorders, it is required that the control of the cutaneous circulation and its integration with general cardiovascular control be fully understood and appreciated. Aims for the next funding period are generally grouped into three related categories, all involved in the efferent side of reflex control of the cutaneous circulation. These are (a) a thorough and specific examination of the reflex control of the active vasodilator system by baroreceptors, skin temperature and exercise. (b) The postulated series linkage between the reflex control of sweating and of the active cutaneous vasodilator system will be critically tested by monitoring the activity of each while thermoregulatory and non-thermoregulatory reflexes are engaged. It is our hypothesis that parallel patterns of response will be seen with thermoregulatory reflexes, but clear differences in pattern between active vasodilator activity and sweating will accompany exercise or baroreceptor reflexes. (c) To find the roles of physical factors in the skin, first we will examine critically the proposition that the cutaneous vascular responses to local heat or cold are an adrenergically mediated event and find out the role of background vasoconstrictor vasodilator activity in the vascular responses to local heating and cooling of the tissue. Second, we will seek to find whether the distensibility of the resistance vessels can play a role in changes in cutaneous vascular resistance which occur with increased arterial blood pressure.