REGULATION OF SKIN BLOOD FLOW IN MAN

皮肤循环具有潜在的血液流动能力 大约8升/分钟，仅次于活跃的骨骼肌， 血液流动的潜在量的术语。 因此 皮肤对体温调节、血压 调节和一般心血管稳态。 大程度 由反射控制（去甲肾上腺素能以及活性 血管扩张系统），皮肤中的阻力血管参与 体温调节反射（内部温度，皮肤 温度）和非温度调节反射 （压力感受器、与运动相关的反射、潜水反射）。 本建议的目的是进一步探讨一体化 这些反射，特别是温度调节的整合 和非体温调节反射。 因此，独立角色 的肌肉质量，运动模式和运动水平， 皮肤脉管系统的反射性血管收缩剂控制将 为了更好地理解反射刺激， 运动促进局部血管反射 反应，并与体温调节反射竞争， 控制皮肤血液流动。 皮肤温度的作用 皮肤血管舒张和心输出量的变化 将确定伴随的长时间动态锻炼。 体温调节和非体温调节的整合 确定血管收缩和血管扩张活性的反射 将通过检查皮肤血管舒张反应进行研究 压力感受器刺激在凉爽，中性和温暖的条件。 潜水反射将在不同的温度下进行研究， 皮肤参与的程度是严格的 体温调节反应 我们还将探索区域 上述皮肤血管反应的异质性 反射反应 只有通过增加我们对 这种对皮肤血流的综合控制， 热应激对循环系统的影响， 疾病

The cutaneous circulation has a potential capacity for blood flow of around 8 liters/minute, second only to active skeletal muscle in terms of a potential magnitude for blood flow. Consequently, the skin has importance for temperature regulation, blood pressure regulation and general cardiovascular homeostasis. Largely controlled by reflexes (noradrenergic as well as an active vasodilator system), resistance vessels in skin participate in thermoregulatory reflexes (internal temperature, skin temperature) and in non-thermoregulatory reflexes (baroreceptors, reflexes associated with exercise, diving reflex). The aim of this proposal is a further exploration of the integration of these reflexes, specifically the integration of thermoregulatory and non-thermoregulatory reflexes. Thus, the independent roles of muscle mass, mode of exercise and level of exercise in the reflex vasoconstrictor control of the cutaneous vasculature will be determined in order to better understand the reflex stimuli associated with exercise in promoting reflex regional vascular responses and in competing with thermoregulatory reflexes in the control of skin blood flow. The role of skin temperature in the cutaneous vasodilation and the changes in cardiac output accompanying prolonged dynamic exercise will be determined. The integration of thermoregulatory and nonthermoregulatory reflexes in determining vasoconstrictor and vasodilator activities will be investigated by examining cutaneous vasodilator responses to baroreceptor stimulation in cool, neutral and warm conditions. The diving reflex will be studied at different temperatures to find the extent to which the cutaneous participation is strictly a thermoregulatory response. We will also explore regional heterogeneity in the cutaneous vascular responses in the above reflex responses. Only through increasing our understanding of this integrative control of skin blood flow can we fully appreciate the impact of heat stress on a circulatory system compromised by disease.