课题基金 / 基金详情

MOLECULAR BASIS FOR HEMOPHILIA B

MOLECULAR BASIS FOR HEMOPHILIA B
B 型血友病的分子基础
批准号：
3342580
负责人：
PUDUR JAGADEESWARAN
金额：
$13.7万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-07-01 至 1987-06-30
来源：
https://reporter.nih.gov/project-details/3342580
关键词：
autoradiography biological polymorphism coagulation factor IX computer assisted diagnosis congenital blood protein disorder electrophoresis endonuclease gene mutation genetic mapping hemophilia B human subject major histocompatibility complex molecular cloning molecular pathology nucleic acid sequence population genetics prenatal diagnosis

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中文摘要
翻译
目前提议的目标是克隆人类并对其进行测序
英文摘要
The objective of the current proposal is to clone and sequence the human Factor IX genes from both normal individuals and individuals suffering from hemophilia B in order to define the molecular mutations in hemophilia B. Cloning will be accomplished by using lambda vectors. Nucleotide sequenced will be determined by the Maxam-Gilbert method and analysed by various computer programs. The restriction endonuclease polymorphisms at the Factor IX gene locus will be analysed. This analysis will provide information on the mutations in hemophilia B. These studies will make the Factor IX genes available. The availability of both normal and defective genes will aid in prenatal and antenatal diagnosis of hemophilia B and also aid in the isolation of genes of related disorders.
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海外基金