RADICAL INTERMEDIATES IN O2 REDUCTION

细胞色素氧化酶(Aa3)对氧代谢的研究 双核铁铜氧化还原中心与单核的比较 细胞色素Omiron类型的氧化酶揭示了基本序列 氧还原反应。在细胞色素(Aa3)氧化酶中形成 结合的过氧化氢，过氧化键的断裂和生成 自由基中间体形成隔离和非隔离的步骤 自由基中间体可以使系统在生物上安全或危险， 分别进行了分析。这些自由基反应步骤的光学研究 通过研究金属原子的电荷密度来补充， 配位体壳层的性质以及到最近和邻近的距离 用X-射线研究自由基中间体中的最接近配体 同步辐射测定边缘和EXAFS(扩展X射线 吸收精细结构)性能。这些研究构成了 对常氧和高氧代谢的认识 对于分子解释导致的过程是必不可少的 纤维化和间质性肺疾病。

The study of the metabolism of oxygen by cytochrome oxidase (aa3), a binuclear iron copper redox center as compared with the mononuclear cytochrome Omicron types of oxidases sheds light on the essential sequence reactions in oxygen reduction. In cytochrome (aa3) oxidase the formation of bound peroxides, the rupture of the peroxide bond and the generation of radical intermediates form steps where sequestered and nonsequestered radical intermediates can render the system biologically safe or dangerous, respectively. The optical study of the steps in these radical reactions are complemented by studies of the charge densities of the metal atoms, the nature of the ligand shells and the distance to the nearest and next to nearest ligands in the radical intermediates by the use of X-ray synchrotron radiation to determine the edge and EXAFS (Extended X-Ray Absorption Fine Structure) properties. These studies form the basis for the understanding of normoxic and hyperoxic metabolism of oxygen and are essential to molecular explanations of processes leading to the pathway of fibrotic and interstitial lung disease.