STUDIES OF ATRIAL FLUTTER IN A MODEL

本研究计划的长期目标是应用于 现代电生理学和药理学技术， 更好地理解心房颤动的机制， 心房扑动的治疗，并制定一个改进的基础， 颤动 研究计划的具体目标包括使用 心包炎犬心房扑动模型及多路复用技术 从放置在心房上的240个电极同时记录1）， 描述心房扑动期间折返回路的性质; 2） 研究心房扑动中心的传导性质 再入回路; 3）表征完全瞬态夹带， 心房扑动中断; 4）在心房扑动期间使用快速心房起搏 窦性心律和心房扑动（夹带）期间，以表征 构成心房扑动折返回路的组织中的传导 在右心房中; 5）表征 激活波阵面; 6）研究如何antiembryonic和其他选择 药物作用于心房扑动折返回路; 7）测试疗效 预防心房颤动的选定干预措施 颤动 这些研究将涉及15个假设， 心房扑动的维持、心房扑动的治疗以及 心房扑动的预防 将用于进一步 在该犬模型中表征和研究心房扑动，包括 采用无菌手术建立无菌心包炎犬模型， 使用标准手术技术再次暴露心脏 慢性无菌性心包炎后;使用多重 各种电生理学研究中的记录技术; 使用心脏起搏技术;以及使用标准药理学 用于施用选定药剂的技术。 健康 该项目的相关性是明确的，因为房扑是一个很好的 已知的、临床上麻烦的和不太了解的异常 影响了大量患者 拟议的研究应 提供重要的新信息，以帮助提高认识， 治疗患有这种异常的患者。

The long term objectives of this research plan are to apply contemporary electrophysiological and pharmacological techniques to obtain an improved understanding of the mechanisms responsible for atrial flutter and to develop an improved basis for the treatment of atrial flutter. The specific aims of the research plan include the use of the pericarditis canine model of atrial flutter and multiplexing techniques to record simultaneously from 240 electrodes placed on the atrial 1) to characterize the nature of the reentry circuit during atrial flutter; 2) to study the nature of conduction in the center of the atrial flutter reentry circuit; 3) to characterize fully transient entrainment and interruption of atrial flutter; 4) to utilize rapid atrial pacing during sinus rhythm and during atrial flutter (entrainment) to characterize conduction in tissues that constitute the atrial flutter reentry circuit in the right atrium; 5) to characterize conduction at pivot points of activation wave fronts; 6) to study how antiarrhythmic and other selected agents act on the atrial flutter reentry circuit; 7) to test the efficacy of selected interventions for the prevention of inducibility of atrial flutter. The studies will address 15 hypotheses concerned with the maintenance of atrial flutter, the treatment of atrial flutter, and the prevention of atrial flutter. The methods to be used to further characterize and study atrial flutter in this canine model include the use of aseptic surgery to create the sterile pericarditis canine model, the use of standard surgical techniques to expose the heart again following creation of chronic sterile pericarditis; the use of multiplex recording techniques during the various electrophysiologic studies; the use of cardiac pacing techniques; and the use of standard pharmacological techniques for the administration of selected agents. The health relatedness of the project is clear, in that atrial flutter is a well known, clinically troublesome, and poorly understood abnormality affecting patients in significant numbers. The proposed studies should provide important new information to assist in improved understanding and treatment of patients suffering from this abnormality.