BRAIN MONOAMINES AND CONDITIONED BEHAVIOR

拟议研究的长期目标是了解 中枢神经系统神经递质系统在介导 精神药物的作用和行为的维持。 我们 将集中在多巴胺，去甲肾上腺素，5-羟色胺和伽马氨基 丁酸及其与操作行为的关系。 喂食， 饮酒和运动也将被研究，因为它们是重要的 操作行为的组成部分。 神经递质的作用将是 被药物和/或神经毒素改变。 行为将使用 计算机导向技术。 有两个广泛定义的焦点， 当前应用。 首先，我们将尝试识别 神经递质系统发生时，操作性行为被修改， 抗抑郁药物的管理。 这项研究的目的是 阐明中枢神经系统神经化学的变化， 行为的变化，并可能参与的病理生理学 萧条 第二，我们将尝试识别神经化学物质 中枢神经系统的机制 药物-行为-环境相互作用，以进一步了解相对 药物和环境在行为改变中的作用。

The long-range aim of the proposed research is to understand the role central nervous system neurotransmitter systems play in the mediation of the actions of psychotropic drugs and in the maintenance of behavior. We will focus on dopamine, norepinephrine, 5-hydroxytryptamine and gamma amino butyric acid, and their relationship to operant behavior. Feeding, drinking and locomotion will also be studied since they are important components of operant behavior. The actions of neurotransmitters will be modified by drugs and/or neurotoxins. Behavior will be measured using computer-oriented techniques. There are two broadly defined foci of the current application. First, we will attempt to identify changes in neurotransmitter systems that occur when operant behavior is modified by administration of antidepressant drugs. The goal of this research is to elucidate changes in central nervous system neurochemistry which lead to changes in behavior and which may be involved in the pathophysiology of depression. Second, we will attempt to identify the neurochemical mechanisms in the central nervous system that account for drug-behavior-environment interactions to further understand the relative roles of drugs and the environment in modifications of behavior.