Promotion of NAD+ anabolism to promote lifespan

该项目旨在确定衰老的机制，压力对衰老大脑的作用以及NAD+如何调节这些影响。NAD+维持细胞能量，修复DNA并执行其他基本细胞功能。细胞内NAD+水平，sirtuin活性的基本底物，包括SIRT2，随着年龄的增长，在人类和生理老化的大鼠下降。该项目将研究旨在提高细胞内NAD+水平的药理学策略将维持最佳SIRT2功能以延长寿命并改善体内与年龄相关的认知衰退的机制。潜在的结果包括使用NAD+来改善老年人的大脑健康。

The project aims to identify mechanisms of ageing, the role of stress on the ageing brain and how NAD+ modulates these effects. NAD+ maintains cellular energy, repairs DNA and performs other essential cell functions. Intracellular NAD+ levels, the essential substrate for sirtuin activity including SIRT2, decline with age in humans and physiologically aged rats. This project will investigate the mechanisms by which pharmacological strategies designed to elevate intracellular NAD+ levels will maintain optimal SIRT2 function to extend lifespan and improve age-related cognitive decline in vivo. Potential outcomes include using NAD+ to improve brain health in advanced old age.