How innate lymphoid cells regulate mammalian lung development

该项目旨在确定肺常驻免疫细胞亚群通过调节干细胞促进正常肺发育的能力。肺经常暴露在包括微生物在内的无数环境挑战中。哺乳动物的局部免疫系统保护肺部免受这些挑战。这在生命早期肺还在发育的时候尤为重要。然而，肺部发育受损影响到人类和牲畜，每年造成30亿美元的损失。预期结果是确定正常哺乳动物肺部发育的基本生物学过程，这可能导致预防人类和动物慢性肺部疾病的策略。

This project aims to determine the ability of a subset of lung resident immune cells to promote normal lung development through the regulation of stem cells. The lung is constantly exposed to countless environmental challenges including microbes. Mammals’ local immune systems protect the lung from these challenges. This is particularly important in early-life when the lung is still developing. However, impaired lung development affects humans and livestock, costing >$3 billion p.a. The intended outcome is to identify basic biological processes involved in normal mammalian lung development, which may lead to strategies to prevent chronic lung diseases in humans and animals.