SERVICES TRIAL METHODS: CLOZAPINE COST EFFECTIVENESS

（摘自申请人摘要）：氯氮平是一种新型的 可能对服务利用率产生深远影响的精神抑制剂， 难治性、重度和持续性残疾的结局 精神分裂症患者 然而，氯氮平治疗是昂贵的。 的 替代公共精神卫生系统政策的真正财政影响 关于氯氮平治疗的分配应该是已知的。 缺乏 此信息可能导致无法服务此禁用组 这是一种浪费公共资源的浪费。 这些信息 应尽快获得，并以最 适用于公共精神卫生系统关于资源的决定 配置中 因此，一种新的州际和公共学术模式 研究合作建议： 1)借鉴经验丰富的公共精神卫生系统和大学 国家规划工作的调查员， 2)提供设计"工具包"以加快试验规划， 3)提供可获得的，有补贴的咨询，以国家心理健康 审判规划和执行方面的权威， 4)提供国家数据分析支持，以及 5)收集多个州的数据，以扩大结果的相关性。 该方法还为公共学术提供了一个有前途的模式， 就其他紧迫服务进行协作资源分配政策 问题. 拟议的项目将吸引州和大学的调查人员， 规划开发氯氮平成本效益试验"工具包"的活动， 和支助咨询和协调费用， 在多个公共场所进行的合作性氯氮平试验。

(Adapted from applicant's abstract): Clozapine is a new type of neuroleptic that may have a profound impact on the service utilization and outcomes of treatment-resistent, severely and persistently disable schizophrenic patients. However, Clozapine treatment is expensive. The true financial impact of alternate public mental health system policies regarding the allocation of Clozapine treatment should be known. Lack of this information may result in both failure to serve this disabled group effectively and a waste of public treatment resources. This information should be obtained as soon as possible and in a form that is most applicable to public mental health system decisions regarding resource allocation. Therefore, a new model of interstate and public-academic research collaboration is proposed that: 1) Draws upon experienced public mental health system and university investigators for a national planning effort, 2) Offers a design "kit" to speed the planning of trials, 3) Offers accessible, subsidized consultation to state mental health authorities on trial planning and execution, 4) Offers a national data analysis support, and 5) Pools multi-state data to broaden the relevance of results. The approach also offers a promising model for public-academic collaboration on other pressing services resource allocation policy questions. The proposed project will engage state and university investigators in planning activities to develop a Clozapine cost-effectiveness trial "kit", and support consultation and coordination costs for implementing a cooperative Clozapine trial at multiple public sites.