NEUROGENETICS OF BEHAVIOR MUTANTS

构成神经结构的大分子被构建和组装 根据遗传信息。我们的目标是研究基因如何控制 神经系统的结构和功能。行为变种人 在果蝇中分离的黑腹果蝇，包括那些有条件的 瘫痪的变种人。这些都是从动物和基因上表现出来的。 对幼虫肌肉进行细胞内记录，以识别和分析 那些在神经传导、神经肌肉传递或 肌肉反应。在我们一直在研究的突变体中，有一些 阻断动作电位的传播(例如，NAP TS、PARTS)和那些 引起动作电位的重复激发(例如，Sh，bas MW1)。功能性 组成神经细胞膜的各种基因产物之间的关系如下 通过检查双突变体中的上位性和抑制性相互作用进行研究。 目前正在进行额外突变体的分离，以进一步扩大我们的 膜兴奋性的遗传修饰谱。这一分析 为最终鉴定分子建立了一个框架 神经系统的组成部分，可能会更好地了解 人类某些遗传性神经疾病的潜在缺陷。

The macromolecules comprising neural structures are constructed and assembled according to genetic information. Our objective is to study how genes control the structure and function of the nervous system. Behavioral mutants are isolated in Drosophila melanogaster including those that are conditional paralytic mutants. These are characterized beaviorally and genetically. Intracellular recordings are performed on larval muscle to identify and analyze those mutants with defects in nerve conduction, neuromuscular transmission, or muscle response. Among those mutants that we have been studying are those that block the propagation of action potential (e.g. nap ts, para ts) and those that cause repetitive firing of action potentials (e.g., Sh, bas MW1). Functional relationships among the various gene products comprising neuronal membranes are studied by examining epistatic and suppressive interactions in double mutants. Isolation of additonal mutants is being carried out to further extend our spectrum of genetic modifications of membrane excitability. This analysis establishes a framework for the eventual identification of the molecular components of the nervous system and may provide a better understanding of the underlying defect in certain heritable neurological disorders in humans.