FASEB SRC: The Genetic Recombination and Genome Rearrangements

FASEB SRC：基因重组和基因组重排

• 批准号: 10539414
• 负责人: NEIL HUNTER
• 金额: $ 0.61万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-12 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10539414
• 关键词: American; Area; Biochemistry; Biological Markers; Biological Models; Biology; Biophysics; Cancer Etiology; Cellular biology; Chemotherapy and/or radiation; Chromatin Structure; Collaborations; Colorado; Communities; DNA Damage; DNA Double Strand Break; DNA Repair Pathway; DNA lesion; Data Set; Development; Discipline; Event; Exposure to; Feedback; Fostering; Genetic; Genetic Recombination; Genome; Genomics; Goals; Laboratories; Malignant Neoplasms; Meiotic Recombination; Mind; Molecular; Oncogenic; Participant; Pathologic; Physiological; Postdoctoral Fellow; Process; RNA metabolism; Reaction; Records; Regulation; Reporting; Research; Research Personnel; Rewards; Scientist; Series; Signal Transduction; Societies; Students; Sum; System; Techniques; Time; Tumor Suppressor Proteins; Woman; anticancer research; base; biological systems; cancer therapy; career; crosslink; data exchange; design; diversity and equity; graduate student; homologous recombination; improved; innovation; innovative technologies; insight; interest; meetings; novel; novel strategies; posters; programs; repaired; side effect; summer research; symposium; technological innovation; telomere; unpublished works

Project Summary/Abstract This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) Summer Research Conference (SRC) on Genetic Recombination and Genome Rearrangements, to be held August 14-19, 2022 in Steamboat Springs, Colorado. This will be the 19th in a series of highly successful biennial conferences devoted to these topics. This conference aims to bring together diverse investigators studying broad aspects of genetic recombination, in a range of biological systems and using different experimental approaches. Presentations will describe cutting-edge unpublished work on timely questions in the field and will foster discussions among diverse groups of participants at all career stages. This FASEB conference will provide unique opportunities for the open exchange of data and technological innovations that can be assimilated and exploited across the entire field. The topics of Genetic Recombination and Genome Rearrangements cover many areas directly relevant for cancer. Homologous recombination is essential to limit genome rearrangements that promote the oncogenic state, and many factors involved recombination and its regulation are tumor suppressors. Hence, studies of recombination are paramount to understanding cancer etiology, to developing much needed biomarkers, and to identifying new tumor suppressors. In addition, systemic or localized DNA damage induced by chemotherapy or radiation remains a major mode of cancer treatment. Recombination is a major pathway for the repair of the DNA double-strand breaks and interstrand crosslinks that result from these therapies. Therefore, understanding the regulation and mechanism of recombination will inform novel and more efficacious strategies of cancer therapy. The FASEB conference brings together investigators from diverse disciplines, including biochemistry, biophysics, genetics, genomics, and cell biology, that cover all aspects of recombination. Key topics to be covered in 2022 include (i) the molecular mechanisms that underpin each step in the recombination reaction, (ii) meiotic recombination, (iii) telomere dynamics, (iv) genome rearrangements that occur during the development of cancer, (v) the relationships between RNA metabolism and recombination, (vi) repair of replicated-associated DNA lesions, (vii) the influence of chromatin structure on recombination, and (viii) DNA damage signaling. Special emphasis on these topics is reflected in our initial speaker invitations. In addition, 21 plenary session talks (about one- third of the total) will be selected from abstracts with an emphasis on late-breaking advances from underrepresented and early-stage scientists. A number of innovations to the conference plan and program aim to further enhance participation, interaction, exchange and discussion among a diverse group of participants; and increase the exposure of younger scientists. In sum, the FASEB SRC on Genetic Recombination and Genome Rearrangements remains the most important conference on a topic of the highest interest and importance to cancer research and the scientific community.

项目摘要/摘要 本申请寻求对美国实验生物学学会联合会的部分支持 (FASEB)关于基因重组和基因组重排的夏季研究会议(SRC)，以 将于2022年8月14日至19日在科罗拉多州的斯普林斯举行。这将是一系列高度重视的 成功举办了专门讨论这些专题的两年期会议。这次会议旨在将不同的 研究人员在一系列生物系统中研究基因重组的广泛方面，并使用 不同的实验方法。演示文稿将描述有关Time的前沿未发表工作 这将促进不同群体的参与者在职业生涯的各个阶段进行讨论。这 FASE B会议将为公开交换数据和技术提供独特的机会 可以在整个领域被吸收和利用的创新。基因重组的主题 基因组重排覆盖了许多与癌症直接相关的领域。同源重组是 对限制促进致癌状态的基因组重排至关重要，涉及许多因素 重组及其调控是肿瘤抑制因子。因此，对重组的研究对 了解癌症病因，开发急需的生物标记物，并识别新的肿瘤 抑制者。此外，化疗或放疗引起的全身性或局部性DNA损伤仍是一种 癌症治疗的主要模式。重组是DNA双链修复的主要途径 这些疗法导致的断裂和链间交联。因此，理解规则和 重组的机制将为肿瘤治疗提供新的、更有效的策略。FASE B 会议汇集了来自不同学科的研究人员，包括生物化学、生物物理学、遗传学、 基因组学和细胞生物学，涵盖重组的方方面面。2022年将涵盖的主要主题包括(I) 重组反应中每一步的分子机制：(Ii)减数分裂重组， (Iii)端粒动态，(Iv)在癌症发展过程中发生的基因组重排，(V) RNA代谢和重组之间的关系，(Vi)复制相关DNA损伤的修复， (Vii)染色质结构对重组的影响；(Viii)DNA损伤信号。特别强调 在我们最初的演讲者邀请中也反映了这一点。此外，21次全会会谈(约一次- 总数的三分之一)将从摘要中选择，重点放在以下方面的最新进展 代表不足和处于早期阶段的科学家。对会议计划和节目目标进行了一些创新 进一步加强各参与方之间的参与、互动、交流和讨论； 并增加年轻科学家的曝光率。综上所述，FASEB关于基因重组的SRC和 基因组重排仍然是关于一个最感兴趣的话题的最重要的会议 对癌症研究和科学界的重要性。