CHILD AND PARENT ADD--BRAIN FUNCTION AND PSYCHOPATHOLOGY

一组108名未经推荐的随机选择的小学生， 在一年级时被诊断出是否存在注意力缺陷 注意力不集中症（ADD）及其注意力不集中和冲动的组成症状， 将在七年级和八年级进行随访。 精神病理学， 神经心理学和电生理学测量将在 这一次要确定： (a)ADD的一级诊断的可靠程度，或 坚持到七年级和八年级; (b)在上述测量领域中， ADD的一级症状;以及 (c)一年级的注意力不集中和冲动的不同作用， 预测七、八级异常。 上述先证者的父母将在相同的领域进行测量， 在记忆期间增加局部脑血流测量 和选择性注意力任务表现。 将使用父数据： (a)对于症状中儿童-父母相关性的定义， 测量ADD的表现，导致制定和测试 遗传假说;以及 (b)用于神经心理学、电生理学和 母体样本内的局部脑血测量。

A cohort of 108 unreferred, randomly selected elementary school students, diagnosed in the first grade for presence or absence of attention deficit disorder (ADD) and its constituent symptoms of inattention and impulsivity, will be followed up in seventh and eighth grade. Psychopathological, neuropsychological, and electrophysiological measurements will be made at this time to determine: (a) the degree to which a first grade diagnosis of ADD is reliable or persistent until seventh and eighth grade; (b) what abnormalities persist -- in the above measurement domains -- from first grade symptoms of ADD; and (c) the differential role of first grade inattention and impulsivity in the prediction of seventh and eighth grade abnormalities. Parents of the above probands will be measured in the same domains, with the addition of regional cerebral blood flow measurements during mnestic and selective attention task performance. The parent data will be used: (a) for the definition of child-parent correlations in the symptoms and measured manifestations of ADD, leading to the formulation and test of genetic hypotheses; and (b) for cross-validation of neuropsychological, electrophysiological, and regional cerebral blood measurements within the parent sample.