IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
批准号:
3394050
负责人:
NICHOLAS W SEEDS
金额:
$10.71万
依托单位国家:
美国
项目类别:
财政年份:
1976
资助国家:
美国
项目状态:
已结题
起止时间:
1976-09-01 至 1989-06-30
关键词:
autoradiography brain cell cell adhesion cell aggregation cell cell interaction cell differentiation cell migration cell sorting cerebellum chromatography electron microscopy electrophoresis electrophysiology embryo /fetus embryo /fetus tissue /cell culture gel electrophoresis histology hybridomas membrane activity monoclonal antibody myelination neuroanatomy neurochemistry neurons newborn animals plasminogen activator synapses tissue /cell culture
中文摘要
研究将针对阐明的生化性质,
细胞间相互作用影响发育和分化,
中枢神经系统 新生小鼠的再聚集体和表面培养
小脑将用于监测生化和形态学
发展 细胞表面成分在细胞迁移和
将使用兔抗血清或小鼠杂交瘤评估髓鞘形成
针对特定细胞表面分子的免疫球蛋白。 的作用
纤溶酶原激活剂在颗粒细胞迁移中的作用将在
使用特异性蛋白水解抑制剂和抗体,
鼠组织纤溶酶原激活剂和尿激酶。
英文摘要
Investigations will be directed at elucidating the biochemical nature of
cell-cell interaction that influence development and differentiation in the
central nervous system. Reaggregate and surface cultures of neonatal mouse
cerebellum will be used to monitor biochemical and morphological
development. The role of cell surface components in cell migration and
myelination will be assessed using rabbit antisera or mouse hybridoma
immunoglobulins directed against specific cell surface molecules. The role
of plasminogen activator in granule cell migration will be examined both in
vitro and in vivo using specific proteolytic inhibitors and antibodies to
murine tissue plasminogen activator and urokinase.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Proteases in Spinal Cord Plasticity & Regeneration
-
批准号:6629430
-
项目类别:
-
资助金额:$32.19万
-
财政年份:2002
-
负责人:NICHOLAS W SEEDS
-
依托单位:
Proteases in Spinal Cord Plasticity & Regeneration
-
批准号:6506070
-
项目类别:
-
资助金额:$30.45万
-
财政年份:2002
-
负责人:NICHOLAS W SEEDS
-
依托单位:
Proteases in Spinal Cord Plasticity & Regeneration
-
批准号:8317869
-
项目类别:
-
资助金额:$17.02万
-
财政年份:2002
-
负责人:NICHOLAS W SEEDS
-
依托单位:
Proteases in Spinal Cord Plasticity & Regeneration
-
批准号:6743224
-
项目类别:
-
资助金额:$32.39万
-
财政年份:2002
-
负责人:NICHOLAS W SEEDS
-
依托单位:
Proteases in Spinal Cord Plasticity & Regeneration
-
批准号:7059983
-
项目类别:
-
资助金额:$32.14万
-
财政年份:2002
-
负责人:NICHOLAS W SEEDS
-
依托单位:
Proteases in Spinal Cord Plasticity & Regeneration
-
批准号:6878473
-
项目类别:
-
资助金额:$32.8万
-
财政年份:2002
-
负责人:NICHOLAS W SEEDS
-
依托单位:
Proteases in Spinal Cord Plasticity & Regeneration
-
批准号:7895927
-
项目类别:
-
资助金额:$20.27万
-
财政年份:2002
-
负责人:NICHOLAS W SEEDS
-
依托单位:
DEVELOPMENTAL NEUROBIOLOGY TRAINING
-
批准号:2195567
-
项目类别:
-
资助金额:$7.27万
-
财政年份:1993
-
负责人:NICHOLAS W SEEDS
-
依托单位:
DEVELOPMENTAL NEUROBIOLOGY TRAINING
-
批准号:2332201
-
项目类别:
-
资助金额:$7.56万
-
财政年份:1993
-
负责人:NICHOLAS W SEEDS
-
依托单位:
DEVELOPMENTAL NEUROBIOLOGY TRAINING
-
批准号:2195568
-
项目类别:
-
资助金额:$7.33万
-
财政年份:1993
-
负责人:NICHOLAS W SEEDS
-
依托单位:
DEVELOPMENTAL NEUROBIOLOGY TRAINING
-
批准号:2195564
-
项目类别:
-
资助金额:$6.81万
-
财政年份:1993
-
负责人:NICHOLAS W SEEDS
-
依托单位:
DEVELOPMENTAL NEUROBIOLOGY TRAINING
-
批准号:2195565
-
项目类别:
-
资助金额:$7.33万
-
财政年份:1993
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:2261781
-
项目类别:
-
资助金额:$20.56万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:2261780
-
项目类别:
-
资助金额:$21.86万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:3394057
-
项目类别:
-
资助金额:$19.12万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:3394052
-
项目类别:
-
资助金额:$8.99万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:2735518
-
项目类别:
-
资助金额:$23.21万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:2445675
-
项目类别:
-
资助金额:$21.18万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:3394051
-
项目类别:
-
资助金额:$15.65万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
IN VITRO BIOCHEMICAL DIFFERENTIATION OF NERVE CELLS
-
批准号:2261779
-
项目类别:
-
资助金额:$20.91万
-
财政年份:1976
-
负责人:NICHOLAS W SEEDS
-
依托单位:
海外基金