STUDIES ON CEREBELLAR MICROZONES

该项目旨在绘制化学指定的浦肯野分布图 细胞在大鼠的小脑皮质，并将其模式与 小脑皮质的传入神经的旁视区。 免疫细胞化学方法将用于识别和追踪传入 系统. 电子显微镜将用于关联的微区 化学上特异的浦肯野细胞，具有特殊来源的传入神经。 这些研究开辟了神经解剖学的新领域， 大脑的结构是根据所做的连接列表来分析的。 由化学上特定的神经元组成。 小脑回路可以作为 哺乳动物大脑其他部分的模型。 由于小脑是一个 控制运动的重要整合中心，遗传的 小脑变性、帕金森病和小脑 与慢性酒精中毒、硫胺素缺乏和 一氧化碳中毒

This project aims to map the distribution of chemically specified Purkinje cells in the rat's cerebellar cortex and to correlate their pattern with the parasagittal zones of identified afferents to the cerebellar cortex. Immunocytochemical methods will be used to identify and trace the afferent systems. Electron microscopy will be used to correlate the microzones of chemically specific Purkinje cells with afferents of particular origins. These studies open a new field of neuroanatomy in which the cellular architecture of the brain is analyzed in terms of the connections list made by chemically specified neurons. The cerebellar circuits can serve as a model for other parts of the mammalian brain. Since the cerebellulm is an important integrating center for the control of movement, the hereditary cerebellar degenerations, Parkinson's disease, and the cerebellar degenerations associated with chronic alcoholism, thiamine deficiency, and carbon monoxide poisoning.