NUCLEAR MAGNETIC RESONANCE EVALUATION OF STROKE

脑梗死在美国是一个严重的医学问题。 的事件 发生在这种疾病的急性期，需要进一步 研究是否需要开发有效的治疗方法。 本研究 利用一种新的成像方式，质子磁共振（MR）， 调查：A.脑梗死后1天和7 - 10天的患者， B。手术诱导闭塞后2-8小时以及3和7天， 大脑中动脉 以前在贝勒磁共振实验室所做的工作允许 脑组织中T1、T2和SD的定量体内测量。 在 此外，还将获得猫脑的~（31）P谱。 这些MR 参数将提供关于急性梗死状态的新信息， 大脑组织 该项目将这些数据与以下数据进行比较：（A）形态学 通过患者CT和猫组织学以及（B）血液记录的变化 通过患者的IMP SPECT扫描和123例IMP放射自显影记录血流 在猫身上。 该项目将通过以下方式进一步扩大MR提供的信息： 开发评估脑血流的技术。 这些将是 通过将患者和CAT数据与血流信息进行比较来评估 可从IMP研究中获得。 MR在确定治疗反应方面的有用性将是 在猫中风模型中通过比较对照梗塞 用几种阿片类药物中的一种治疗的猫。

Cerebral infarction is a serious medical problem in the USA. The events which occur in the acute stage of this disease require further investigation if an effective therapy is to be developed. This study utilizes a new imaging modality, proton magnetic resonance (MR) to investigate: A. Patients 1 and 7 - 10 days after cerebral infarction and B. cats 2-8 hours and 3 and 7 days after surgically induced occlusion of the middle cerebral artery. Previous work done at the Baylor MR lab allows quantitative in vivo measurement of T1, T2, and SD in cerebral tissue. In addition, 31P spectra will be obtained in the cat brain. These MR parameters will provide new information on the state of acutely infarcted cerebral tissue. The project compares this data with: (A) morphologic changes documented by CT in patients and histology in cats and (B) blood flow documented by IMP SPECT scans in patients and 123 IMP autoradiography in cats. The project will further expand the information available from MR by developing techniques to assess cerebral blood flow. These will be evaluated by comparing the patient and cat data to the flow information available form the IMP studies. The usefullness of MR in determining the response to therapy will be evaluated in the cat stroke model by comparing the controlled infarctions in cats with the cats treated with one of several opiate anatogonists.