EARLY MARKERS OF ALZHEIMERS DISEASE

阿尔茨海默病的早期标志

• 批准号: 2294170
• 负责人: R N BRYAN
• 金额: $ 64.46万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2294170
• 关键词: EARLY; MARKERS; ALZHEIMERS; DISEASE

Longitudinal studies of participants in the Baltimore Longitudinal Study of Aging (BLSA) have indicated that performance on some cognitive and memory tests declines after age 70. However, there is a great deal of variability among individuals in the trajectories of cognitive aging. Data from our laboratory indicate that early declines in BLSA participants predict later impairments in cognition and memory and that such declines may be early markers of pathological cognitive aging. The contributions of changes in brain structure and function to these differences in cognitive aging are unclear, as neuroimaging data have not been collected systematically for these individuals and there are few studies in the literature of such changes. This project will address this gap through the acquisition and quantification of annual neuroimaging studies of 180 selected BLSA participants (90 males and 90 females, aged 60 years and older) over a 9-year period. State-of-the-art magnetic resonance imaging (MRI) and positron emission tomography (PET) will be used to measure brain anatomy and blood flow, respectively. PET and oxygen-15 labeled water will provide measurements of cerebral blood flow during resting conditions and during the performance of memory tasks to examine functional integrity of the aging brain during cognitive demand. A battery of neuropsychological tests will be administered in conjunction with the neuroimaging evaluations. The principal goals of this project are to address the following questions: 1. Do prior psychological and physical characteristics predict changes in brain structure and function and neuropsychological changes later in life? 2. Are longitudinal changes in brain structure and function associated with changes in cognitive and memory performance? 3. What is the rate of change in brain anatomy and physiology in men and women after the age of 60 years? 4. What is the frequency and progression of brain abnormalities in community-dwelling aged populations? This project will provide critical information for researchers and clinicians on the predictors of normal and pathological cognitive aging in relation to brain abnormalities, which will enhance our understanding of changes in health and diseases of the elderly, such as Alzheimer's Disease.

巴尔的摩纵向研究参与者的纵向研究 老龄化研究（BLSA）表明，某些认知和 70 岁以后记忆力测试会下降。然而，有很多 个体之间认知衰老轨迹的变异性。数据 我们的实验室表明 BLSA 参与者的早期下降 预测后来的认知和记忆障碍以及这种下降 可能是病理性认知衰老的早期标志。的贡献 大脑结构和功能的变化导致这些认知差异 由于尚未收集神经影像数据，衰老情况尚不清楚 系统地针对这些人进行研究，但很少有研究 此类变化的文献。该项目将通过 获取并量化 180 项年度神经影像研究 选定的 BLSA 参与者（90 名男性和 90 名女性，年龄 60 岁， 年长）超过 9 年。最先进的磁共振成像 （MRI）和正电子发射断层扫描（PET）将用于测量大脑 分别是解剖学和血流。 PET 和氧 15 标记水将 提供静息状态下脑血流量的测量，以及 在执行记忆任务期间检查功能完整性 大脑老化过程中的认知需求。一组神经心理学 测试将与神经影像学结合进行 评价。 该项目的主要目标是解决以下问题 问题： 1. 先前的心理和身体特征是否可以预测 大脑结构和功能的变化以及神经心理学的变化 以后的生活？ 2.大脑结构和功能的纵向变化 与认知和记忆表现的变化有关吗？ 3. 什么是 男性和女性的大脑解剖学和生理学变化率 60岁？ 4. 大脑的频率和进展是怎样的 社区老年人口是否存在异常？该项目将 为研究人员和临床医生提供重要信息 与大脑相关的正常和病理性认知衰老的预测因素 异常，这将增强我们对健康变化的理解 以及老年人的疾病，例如阿尔茨海默病。