CARDIA Year 35 Brain MRI Renewal

CARDIA Y35脑MRI更新辅助研究摘要 许多研究已经证实脑血管疾病(CEVD)、形态学 以及生理性的大脑变化，包括中风，认知能力下降和痴呆症，包括阿尔茨海默氏症 疾病及相关障碍(ADRD)。新的生理和功能磁共振成像(FMRI)方法允许非 有创性测量局部脑血流量、血管反应性和生理性脑连通性。 这些技术提供了评估形态、病理生理学和脑功能障碍的手段。 与CEVD和ADRD有关。 CARDIA第25年和第30年的脑MRI子研究旨在纳入最先进的MRI 将技术引入相对年轻的CARDIA人群，以确定磁共振成像与心血管疾病风险的相关性 因素和检测早期CEVD。这些研究记录了CEVD的早期mri改变。 与心血管疾病危险因素的相关性，特别是高血压。CARDIA Year 35 MRI辅助研究是 旨在将这些早期研究扩展到CARDIA的中年晚期人口。 CEVD和ADRD的大多数生物标志物在大约55岁之前都是弱表达的，当它们开始 陡峭的上升到陡峭的斜坡，在生命的第六和第七个十年中显而易见。相应地，亚临床 疾病在临床上变得明显，表现为生理变化和认知缺陷的增加。 然而，混淆CEVD的影响的是年龄、生活方式和包括ADRD在内的共病。卡迪亚， 凭借其冗长而丰富的历史数据，可以很好地剖析CEVD和推定的错综复杂的 在从中年向老年过渡的过程中与ADRD的关系，从很少合并疾病和 药物使用率低。 约1044名参与者将从四个参与的外地中心登记参加辅助研究。 MRI参与者将从以前的CARDIA脑MRI参与者中招募，并接受脑MRI扫描 以及为Y25和Y30定义的认知测试。将报告核磁共振数据的计算机分析 按感兴趣的解剖区域定量。 主要目标是：1)加强统计能力，以便更好地记录上述文件和新文件 人口学测量、危险因素和脑MRI结果之间明确的关联，2)定义MRI 与临床事件和认知变化最相关的参数，以及3)识别早期MRI 在个体水平上告知疾病病理生理学和进展的生物标志物模式。

CARDIA Y35 Brain MRI Renewal Ancillary Study Abstract Many studies have established strong relationships between cerebrovascular disease (CEVD), morphological and physiological brain changes, including stroke, and cognitive decline and dementia, including Alzheimer disease and related disorders (ADRD). New physiological and functional MRI (fMRI) methods allow non- invasive measurement of regional cerebral blood flow, vascular reactivity and physiological brain connectivity. These techniques provide the means to evaluate the morphology, pathophysiology, and brain dysfunction related to CEVD and ADRD. The CARDIA Year 25 and Year 30 Brain MRI Substudies were designed to incorporate state-of-the-art MRI technology into the relatively younger population of CARDIA in order to determine MRI correlates of CVD risk factors and detect early CEVD. These studies documented early MRI changes of CEVD with strong correlations to CVD risk factors, particularly hypertension. The CARDIA Year 35 MRI Ancillary Study is intended to extend these earlier studies into the late middle age population of CARDIA. Most biomarkers of CEVD and ADRD are weakly expressed until approximately age 55, when they begin their precipitous rise to the steep slope evident in the 6th and 7th decades of life. Correspondingly, subclinical disease becomes clinically evident, reflected by increasing physiological changes and cognitive deficits. However, confounding the effects of CEVD are age, lifestyle, and co-morbidities, including ADRD. CARDIA, with its lengthy and rich historical data, is well-positioned to dissect the intricacies of CEVD and putative relationship to ADRD in the transition from middle age to seniority, starting at ages with few comorbidities and low medication use. Approximately 1044 participants will be enrolled in the Ancillary Study from the four participating Field Centers. MRI participants will be recruited from previous CARDIA Brain MRI participants and receive brain MRI scans and cognitive testing as defined for Y25 and Y30. Computer analysis of MRI data will be reported quantitatively by anatomic regions-of-interest. The primary objectives are to: 1) enhance statistical power to better document previously described and newly defined associations between demographic measures, risk factors and brain MRI findings, 2) define MRI parameters most strongly associated with clinical events and cognitive changes, and 3) identify early MRI biomarker patterns that inform disease pathophysiology and progression at an individual level.