An Investigation of Multicomponent Azole Chemistry within a Generational System for the Expression the Canonical Genetic Structures

生命潜在的生物化学统一性暗示了生命的化学起源，事实上，有机化学源于合成、表征和理解生命的化学成分的愿望，而天然产品和生物催化剂是有机化学所能取得的成就的基准。尽管在其间的两个世纪里科学取得了进步，但发现启动生命的化学变化是现代科学正在解决的最重要、最基本和最具挑战性的化学问题之一。有三类大分子是所有现存生命绝对必需的-DNA、RNA和蛋白质。我们试图在实验中建立两类核酸和蛋白质的世代需求之间的联系。将实施一项系统化学研究计划，以阐明佐证化学途径，以了解DNA、RNA和蛋白质等关键组成分子的世代关系和共性。该研究金建议的工作旨在促进有机硫化学和非生物发生中多组分反应的未开发潜力。在有机化学的总体背景下，更具体地说，在生命研究的起源方面，多组分反应的潜力肯定被认为是快速而简洁地建立分子复杂性的关键因素。与绝大多数以异腈为关键成分的多组分反应不同，本提案中概述的工作以氮唑为多组分反应的基本元素。将开发新的三组分和四组分反应性。此外，硫的反应性将被利用来获得新的反应基序，从而允许发现未知的化学和化学途径。在整个研究过程中，将发现新的绿色化学反应和多组分反应。我们将继续发展系统化学，以拓宽和加深对如何利用系统化学来获得具有商业重要性的产品，以及更重要的是，生物组成大分子作为一个化学系统的产品的世代关系的理解。

The underlying biochemical unity of life suggests a chemical origin of life, indeed organic chemistry arose from the desire to synthesise, characterise and understand the chemical constituents of life, and natural products and biocatalysts are benchmarks for what can be achieved in organic chemistry. Despite the scientific advances of the intervening two centuries, discovering the chemical transformations that initiated life represents one of the most important, fundamental and challenging chemical questions being addressed by modern science.There are three classes of macromolecules that are absolutely necessary for all extant life-DNA, RNA and proteins. We seek to experimentally establish a link between the generational requirements of both classes of nucleic acid and proteins. A systems chemistry research programme will be implemented to elucidate corroborative chemical pathways to understand the generational relationship and commonality of the key constituent molecules of DNA, RNA and proteins.The work proposed in this fellowship is designed to advance the undeveloped potential of both organosulfur chemistry and multicomponent reactivity in abiogenesis. Within the overall context of organic chemistry and, more specifically, origins of life research, the potential of multicomponent reactions has certainly been recognized as a key element for rapid and succinct build-up of molecular complexity. In contrast to the vast majority of multicomponent reactions, which feature an isonitrile as the key component, the work outlined in this proposal features azoles as an essential element for multicomponent reactivity. New three- and four-component reactivity will be developed. Furthermore, the reactivity of sulfur will be exploited to access new reactivity motifs, allowing unexplored chemistry and chemical pathways to be discovered. Throughout the course of this fellowship new green chemical reactivity and multicomponent reactions will be discovered. We will continue to develop systems chemistry to broaden and deepen the understanding of how systems chemistry can be used to access commercially important products and, significantly, the generational relationship of the constituent macromolecules of biology as the products of one chemical system.