HORMONAL AND EXPERIENTIAL EFFECTS ON BEHAVIOR

成年雄性对婴儿的暴力行为被认为发生在许多物种中， 但对影响这些因素的了解相对较少。 成年雄性对幼鸟的行为。 这本书中的实验 关于规范杀害幼畜行为的提案， 雄性家鼠（Mus musculus）的父母行为。 我最近发现， 交配经验显著影响雄性小鼠的行为， 年轻：在交配后12到50天，大多数雄性表现出父母般的行为 向年轻人，而在此之前和之后，大多数男性承诺 杀了他 这一发现的显著特点是， 交配后19天出生，50天左右断奶 交配后的几天。 因此，雄性小鼠被抑制 在交配后杀死婴儿的时间正好是他们可以在 与自己的后代接触。 先前的实验表明， 交配本身，而不是承认一个单独的女性和她的 年轻人，会引发这些行为上的变化 第一套建议 实验将提供有关刺激的信息， 交配和感觉通路参与调解这些变化， 行为 此外，参与介导抗抑郁药的大脑区域 父母的行为将被调查 最后，实验 确定垂体和/或性腺激素是否影响 将进行交配后对幼仔的行为。 第二组实验将涉及检查雄性小鼠， 在子宫内，两个雄性胎儿（2M雄性）之间，一个雄性和一个雌性之间 胎仔（1M雄性）和两个雌性胎仔之间（OM雄性）。 OM雄性 胎儿在胎儿生命期间暴露于高滴度的雌二醇， 200万男性胎儿，大多数性幼稚的成年OM男性 当大多数性幼稚的成年2M雄性表现出父母般的行为时， 向年轻人（1M男性的行为介于OM和2M之间 男性）。 OM、1M和2M雄性小鼠将通过剖腹产分娩， 在成年期检查他们对年轻人的行为，无论是之前还是之后， 交配 因此，本实验将评估先前的子宫内 立场限制了成人经验对行为的影响程度 对年轻的雄性小鼠。

Violence toward infants by adult males is thought to occur in many species, but relatively little is known about the factors which influence the behavior of adult males toward young. The experiments contained in this proposal concern the regulation of infanticide (the killing of young) and parental behavior in male house mice (Mus musculus). I recently found that experience mating markedly influences the behavior of male mice toward young: between 12 and 50 days after mating most males behave parentally toward young, while before and after this time most males commit infanticide. The striking feature of this finding is that a male's own young would be born 19 days after mating and then normally weaned bout 50 days after mating. Thus, male mice are inhibited from committing infancticide after mating exactly during the time that they could be in contact with their own offspring. Previous experiments have revealed that mating per se, rather than recognition of an individual female and her young, triggers these changes in behavior. The first set of proposed experiments will provide information concerning the stimuli associated with mating and the sensory pathways involved in mediating these changes in behavior. In addition, the brain areas involved in mediating infanticide and parental behavior will be investigated. Finally, experiments to determine whether pituitary and/or gonadal hormones influence changes in behavior toward young after mating will be conducted. The second set of experiments will involve examining male mice that develop in utero between two male fetuses (2M males), between a male and a female fetus (1M males), and between two female fetuses (OM males). OM male fetuses are exposed to high titers of estradiol during fetal life relative to 2M male fetuses, and most sexually-naive adult OM males commit infanticide while most sexually-naive adult 2M males behave parentally toward young (1M males are intermediate in behavior between OM and 2M males). OM, 1M and 2M male mice will be delivered by Cesarean section and examined in adulthood for their behavior toward young both before and after mating. This experiment will thus assess whether prior intrauterine position limits the degree to which adult experience can influence behavior toward young in male mice.