Fully-Integrated Continuous Flow Processes for Access to Forbidden Chemistries, New Reactivities and Sequential Complexity Generation

可持续性和大大改进的化学过程正在推动化学合成的变化步伐。作为一个社区，我们需要发现新的反应和新型的化学反应，这些反应更清洁，并提供具有所需功能的新材料。此外，我们需要大大增强我们使用的合成过程的工具，并朝着集成的机器辅助方法迈进，这将使我们能够捕获最有用的和新兴的硬件设备和软件开发。这就要求我们对分子合成的方法进行彻底的改变。从传统的批量合成分子的操作模式转向连续流处理，可以获得许多好处，这些好处可以提高安全性，减少溶剂的使用，减少浪费。我们提出的研究将展示一种直接解决这些需求的方法，因为它专注于推进流动反应器技术，并利用其独特的功能来解决当代化学问题。使用连续流反应器平台，我们将在新的化学领域发现更可持续和环境可接受的序列，从而产生具有广泛功能特性的新产品，特别是对医疗保健市场有用。为了做到这一点，我们还将设计新的机制，以促进延长工作制度，并将有才能的人从日常的规模扩大和优化任务中解放出来。这些概念将导致当前分子构建实践中的文化变革。在这样做的过程中，这项工作将产生远远超出最初研究方案的长期影响。这项研究的结果将为以前的传统方法无法实现的新型材料提供途径，并可能为进一步开发新的复杂性生成方法开辟仿生途径。

Sustainability and greatly improved chemical processes are driving the pace of change in chemical synthesis. As a community, we need to discover new reactions and new types of chemical reactivity that are cleaner and deliver new materials with desired functions. Furthermore, we need to substantially enhance the tools of the synthesis processes we use and move towards an integrated machine-assisted approach that will allow us to capture the most useful and emerging hardware devices and software developments. This required a radical change in our approach to molecule synthesis. By moving away from traditional batch mode operations for the synthesis of molecules to continuous flow processing many benefits can be gained and these lead to improved safety, lower solvent use and less waste. Our proposed research will demonstrate an approach that will address these needs directly as it focuses on advancing flow reactor technology and harnessing their unique features to solve contemporary chemistry problems. Using continuous flow reactor platforms we will make discoveries in new areas of chemistry following more sustainable and environmentally acceptable sequences leading to new products with wide ranging functional properties particularly useful for the healthcare marketplace. To do this we will also devise new machinery that will facilitate extended working regimes and will release talented individuals from routine scale-up and optimisation tasks. These concepts will lead to a cultural change in the current practice of molecular construction. In doing this, the work will have a long-term impact well beyond the initial research programme. The outcomes from this research should provide access to new types of material not possible from previous conventional approaches and could open up biomimetic pathways for further exploitation leading to new complexity generation methods.