REVERSE CHOLESTEROL TRANSPORT

几组风险较高的人类患者 动脉粥样硬化在序列中显示一致的异常 的反应(“反向胆固醇运输”) 胆固醇从外周细胞到肝脏。目的 这些试点研究是为了确定狒狒是否是一种模型 对于人类大血管疾病，在血浆中有一种胆固醇 运输途径与在人类中发现的相似；以及 无论是遗传因素还是环境因素改变了 中国人动脉粥样硬化和胆固醇转运的发生率 人类在狒狒身上也有类似的作用。 胆固醇逆向转运的速率及其组成 步骤(胆固醇转运到血浆；胆固醇 卵磷脂：胆固醇在血浆中的酯化 酰基转移酶；胆固醇酯转移)将被测量 在狒狒血浆中。初步研究将在#年进行反应速率 正常动物的空腹血浆。随后的测量 将在具有家族遗传的abimal的血浆中 高或低低密度脂蛋白/高密度脂蛋白比值或同时具有高密度脂蛋白和低密度脂蛋白水平 在血浆中降低。餐后脂血症，这会刺激 胆固醇在正常血脂人群中的反向转运将是 检查其对胆固醇反向转运的影响 脂蛋白血症患者和正常人群的脂蛋白组成 这些是狒狒。 所获得的数据将表明在何种程度上 胆固醇酯的生成和分布机制 人类的血浆是在狒狒体内繁殖的。如果这样的一个 这些先导实验显示出相似性，它将使 是否有可能研究胆固醇在体内的沉积情况 大血管与血管异常有直接关系。 相同动物血浆中的胆固醇代谢。

Several groups of human patients at increased risk of atherosclerosis show consistent abnormalities in the sequence of reactions ("reverse cholesterol transport") which carries cholesterol from peripheral cells to the liver. The purpose of these pilot studies is to determine whether the baboon, a model for human macrovascular disease, has in plasma a cholesterol transport pathway similar to that identified in humans; and whether genetic or environmental factors which modify the incidence of atherosclerosis and cholesterol transport in humans, have similar effects in the baboon. The rate of reverse cholesterol transport and its component steps (cholesterol transport into plasma; cholesterol esterification in plasma by lecithin: cholesterol acyltransferase; cholesteryl ester transfer) will be measured in baboon plasma. Initial studies will be of reaction rates in the fasting plasma of normal animals. Subsequent measurements will be in the plasma of abimals with familial inheritance of high or low LDL/HDL ratios or with both HDL and LDL levels decreased in plasma. Postprandial lipemia, which stimulates reverse cholesterol transport in normolipemic humans, will be examined for its effect on reverse cholesterol transport and lipoprotein composition in normal and dyslipoproteinemic baboons. The data obtained will indicate the extent to which the mechanisms which generate and distribute cholesteryl esters in human plasma are reproduced in the baboon. If such a similarity is shown by these pilot experiments, it will make possible an investigation of whether cholesterol deposition in the large vessels is directly related to abnormalities of cholesterol metabolism in the plasma of the same animals.