How do unconventional T cells die?

哺乳动物细胞通过几种不同的机制死亡，每一种机制都在分子水平上受到严格控制。死亡途径的选择取决于触发因素和细胞类型。该项目将研究控制T细胞死亡的机制，包括常规T细胞和非常规T细胞，如粘膜相关不变T （MAIT）细胞，在正常条件下和炎症期间。它结合了我们在体内研究MAIT细胞的方法和细胞死亡分析的专业知识。本项目有望阐明控制T细胞存活/死亡的复杂机制，增加我们对活化T细胞死亡机制的基本认识。

Mammalian cells die via several different mechanisms, each of which is tightly controlled at a molecular level. The choice of death pathway depends on the trigger and cell type. This project will investigate the mechanisms controlling death of T cells, including conventional T cells, and unconventional T cells, such as mucosal-associated invariant T (MAIT) cells, in normal conditions and during inflammation. It combines methods we developed to study MAIT cells in vivo with expertise in cell death analysis. This project is expected to elucidate the complex mechanisms controlling T cell survival/death and increase our fundamental understanding of cell death mechanisms of activated T cells.