RECENT ADVANCES IN THE BIOMEDICAL SIGNIFICANCE OF TRH

TRH在整个中枢神经系统中分布广泛 与神经功能的作用一致，除了 调节脑下垂体激素分泌。的确，有很多 来自最近人类和其他动物神经生物学研究的证据 动物表明这种物质是一种神经递质或 哺乳动物中枢神经系统中潜在的神经调节剂 生物医学的含义。 这次会议的目的是汇聚知识 从许多不同的显著进步中衍生出来的 在过去五年中发生在 这种三肽酰胺的生物医学作用。它已经建立起来了 TRH是核糖体的产物，而不是酶 生物合成，TRH前体本身就是前体 除了TRH之外，还有一个全新的多肽家族。此外， 在理解这些因素方面取得了重要进展。 调节TRH及其类似物与受体的结合。这个 TRH对大鼠脑内肌醇第二信使系统的影响 脑下垂体提供了一种广泛的 中枢神经系统的作用归因于这种多肽。TRH共本地化于 脑干神经元与另一神经肽P物质和 一种经典的神经递质，5-羟色胺，现在是 认识到所有这些物质的分泌可能是 密切相关的。最后，已经有了重要的临床 研究表明TRH可能在糖尿病中发挥治疗作用 肌萎缩侧索硬化症(ALS)、脊柱创伤和 心血管休克。 这项拟议的会议由纽约学院赞助 将吸引来自广泛领域的科学家 每一门学科都涉及TRH生物学的不同方面。 作为一个论坛，它将把不同形式的调查人员聚集在一起 背景包括分子生物学、神经内分泌学、 药理学、多肽化学、神经生物学、神经化学、 酶学和临床神经学。这次会议将提供 将有关TRH的新信息集成到 多学科时尚，确定特定领域的 神经生物学需要进一步研究和培养协作能力 不同学科的科学家之间的研究。

TRH has a widespread distribution throughout the CNS consistent with a role in neuronal function in addition to regulation of pituitary hormone secretion. Indeed, much evidence from recent neurobiologic studies in man and other animals suggests that this substance is a neurotransmitter or neuromodulator in the mammalian CNS with potential biomedical implication. The purpose of this conference is to coalesce the knowledge derived from the remarkable advance in a number of different areas that have taken place during the past five years in the biomedical role of this tripeptide amide. It has been established that TRH is the product of ribosomal and not enzymatic biosynthesis and that the TRH precursor itself is the progenitor of a whole new family of peptides in addition to TRH. Further, important advances have been made in understanding the factors regulating the binding of TRH and its analogs to receptors. The effects of TRH on inositol second messenger systems in the pituitary provide a neurochemical model for the wide range of CNS action attributed to this peptide. TRH is co-localized in brain stem neurons with another neural peptide, substance P, and a classical neurotransmitter, 5 hydroxytryptamine, and it is now recognized that the secretion of all these substances may be intimately related. Finally, there have been important clinical studies pointing to a possible therapeutic role for TRH in amyotrophic lateral sclerosis (ALS), spinal trauma, and cardiovascular shock. This proposed conference sponsored by the New York Academy of Sciences will attract scientists form a wide range of disciplines, each involved in different aspects of TRH biology. As a forum, it will bring together investigators form diverse backgrounds including molecular biology, neuroendocrinology, pharmacology, peptide chemistry, neurobiology, neurochemistry, enzymology, and clinical neurology. This conference will provide a means of integrating new information on TRH in a multidisciplinary fashion, identifying specific areas of neurobiology requiring further study and fostering collaborative studies between scientists of separate disciplines.