CONFERENCE ON SUBSTANCE P & RELATED PEPTIDES

该提案要求支持召开一次关于“与P物质有关的 肽：细胞与分子生理学。“会议将在 伍斯特，马萨诸塞州，1990年7月19日至21日，并将汇集一个 一大批国内和国际公认的科学家 包括生理学家、药理学家、生物化学家和 分子生物学家 会议的范围将是最近的进展 在外地 两者的结构、表达和调控 前速激肽原基因将被解决，因为将不同的模式， 多种前体的翻译后加工。 一个主要重点 将在分子生物学，生物化学和药理学 P物质和相关物质的多种受体的表征 缩氨酸 拮抗剂的开发继续取得进展 允许对P物质的生理作用进行新的研究。 高选择性的基于肽的受体拮抗剂已经被定义为 在过去的两年里，一个令人兴奋的最近的成就是， 非肽受体拮抗剂的鉴定。 几项研究 与这些拮抗剂有关的问题将在本次会议上报告。 信号 转导机制将从生物化学和 电生理学的观点。 的解剖定位 肽及其受体，及其同源mRNA，以及它们的 与其他神经递质系统的共定位，将得到解决。 最后，P物质和相关肽在特定细胞中的许多功能， 中枢神经区域，在感觉和自主神经系统中， 在生殖道和免疫功能的调节中， 覆盖. P物质与疼痛的传播有关 刺激，炎症反应，关节炎和炎症性肠 疾病 P物质纤维支配脉管系统，包括 冠状循环 因此，物质的可能临床意义 P将被考虑。 希望这次会议将吸引许多年轻人，包括 研究生、博士后研究员和初级教员， 出席并参加预定的海报会议。 请求的 基金将用于帮助支付这些年轻科学家的费用。

This proposal requests support for a conference on "Substance P related peptides: Cellular and molecular physiology." The meeting will be held in Worcester, Massachusetts on July 19-21, 1990, and will bring together a large group of nationally and internationally recognized scientists working in the area, including physiologists, pharmacologists, biochemists and molecular biologists. The scope of the meeting will be on recent advances in the field. The structures, expression and regulation of the two preprotachykinin genes will be addressed, as will the different patterns of posttranslational processing of the multiple precursors. A major focus will be on the molecular biological, biochemical and pharmacological characterization of the multiple receptors for substance P and related peptides. Progress has continued on the development of antagonists permitting new studies on the physiological roles of substance P. Several highly selective peptide-based receptor antagonists have been defined over the past two years, and an exciting recent achievement has been the identification of non-peptide receptor antagonists. Several studies related to these antagonists will be reported at this meeting. Signal transduction mechanisms will be presented from biochemical and electrophysiological points of view. The anatomical localization of the peptides and their receptors, and their cognate mRNAs, as well as their colocalization with other neurotransmitter systems, will be addressed. Finally, the many functions of Substance P and related peptides in specific central nervous regions, in the sensory and the autonomic nervous systems, in the reproductive tract, and in regulation of immune function, will be covered. Substance P has been implicated in the transmission of painful stimuli, in inflammatory responses, in arthritis and in inflammatory bowel disease. Substance P fibers innervate the vasculature including the coronary circulation. Thus the possible clinical implications of substance P will be considered. It is hoped that this meeting will attract many younger persons including graduate students, postdoctoral fellows and junior faculty members to attend and participate in the scheduled poster sessions. The requested funds will used to help defray expenses for these younger scientists.