PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES

在继续研究两个神经元的过程中，计划进行几系列实验 多肽，P物质和神经降压素，已经被分离，测序，和 在这个实验室里合成的。概述的研究包括a)绘制 这些多肽在脑和周围神经中的分布。B)划定 中枢神经系统内含有P物质或神经降压素的束。 C)神经组织中P物质和神经降压素的释放 活着。D)P物质和神经降压素的化学特征 血浆。E)控制血浆免疫活性物质P和 神经降压素。

Several series of experiments are planned in continuing work on two neural peptides, substance P and neurotensin, that have been isolated, sequenced, and synthesized in this laboratory. The studies outlined include a) mapping the distribution of these peptides in brain and peripheral nerve. b) delineation of substance P or neurotensin-containing tracts within the central nervous system. c) the release of substance P and neurotensin from neural tissue in vitro and in vivo. d) the chemical characterization of substance P and neurotensin in plasma. e) manipulation of the plasma levels of immunoreactive substance P and neurotensin.