CONFERENCE--DNA DAMAGE EFFECTS ON STRUCTURE

生物体已经进化出各种系统和途径来维持其生物学特性。 遗传物质的完整性。 近年来， 大量的酶和分子生物学数据描述了这些 途径，并强调其在保护生物体免受 环境破坏剂的有害影响。DNA损伤 已被证明会导致许多有害影响， 突变、肿瘤发生、细胞毒性甚至衰老。 DNA修复的缺陷也与几种人类遗传病有关。 疾病如着色性干皮病、共济失调毛细血管扩张症、布卢姆氏病 综合征、科凯恩综合征、范可尼贫血等。 一些 参与这些疾病的基因，以及一些其他修复 基因已经被克隆，基因治疗的计划也在酝酿之中。 纸板.事实上，DNA修复系统似乎是最重要的系统之一。 在自然界中保守;同源性存在于DNA修复蛋白之间， 细菌对人类本次研讨会的主题是 蛋白质之间的结构/功能关系， DNA损伤和DNA损伤。这个纽约学院的目的是 科学主办的会议是汇集结构生物学家， 化学家和DNA修复酶学家，专注于结构 DNA损伤产生的改变以及这些改变如何影响 生物相关蛋白质如DNA和RNA的识别 聚合酶和修复糖基化酶和内切核酸酶。纪律是 包括一些年轻人在内的发言者很好地代表了这一点。 investigators.海报会议将是本次会议的一个组成部分 并将为年轻的研究人员提供一个额外的场所， 他们的工作。

Organisms have evolved a variety of systems and pathways to maintain the integrity of their genetic material. In recent years there has been an explosion of enzymatic and molecular biological data describing these pathways and highlighting their importance in protecting organisms from the deleterious effects of environmental damaging agents. Damage to DNA has been shown to result in a number of harmful effects including mutation, oncogenesis, cellular cytotoxicity and perhaps even aging. Defects in DNA repair have also been implicated in several human genetic diseases such as xeroderma pigmentosum, ataxia telangiectasia, Bloom's syndrome, Cockayne syndrome, Fanconi anemia, among others. Some of the genes involved in these disorders, as well as a number of other repair genes, have been cloned and plans for gene therapy are on the drawing board. In fact, DNA repair systems appear to be one of the most highly conserved in nature; homologies exist among DNA repair proteins from bacteria to humans. The subject of this symposium is the structure/function relationships between the proteins that interact with damaged DNA and the DNA damages. The purpose of this New York Academy of Sciences' sponsored meeting is to bring together structural biologists, chemists, and DNA repair enzymologists, to focus on the structural alterations produced in DNA by damage and how these alterations influence recognition by biologically relevant proteins such as DNA and RNA polymerases and repair glycosylases and endonucleases. The disciplines are well represented by the speakers who include a number of young investigators. Poster sessions will be an integral part of this meeting and will provide an additional venue for young investigators to present their work.