EFFECTS OF MINERAL DUSTS ON CELLS

空气中的纤维和颗粒对职业有重要意义 和环境健康。这些污染物中的许多会导致 呼吸系统疾病，包括肺纤维化(石棉、高岭土、 肺癌(石棉、赤铁矿)和 间皮瘤(石棉、埃里昂石和其他类似纤维 石棉的尺寸)。其他人被认为是病毒的携带者 大气中的化学致癌物，包括多环 香烟烟雾中的芳香烃。一批 微粒或“讨厌的尘埃”(棉花、玻璃)也会引起 可导致皮炎、哮喘的炎性变化 和慢性呼吸道疾病。 矿物粉尘导致细胞损伤和 细胞增殖和/或分化的改变尚不清楚。 这次会议的目的(将于1988年9月21日至23日在 加拿大魁北克舍布鲁克)，这是一系列 大约每3-4年举办一次国际讲习班， 汇聚了大约125位杰出的科学家 开展最先进的临床和基础研究 纤维和颗粒物对靶细胞的作用机制 疾病。深入讨论的内容包括：物理化学 粉尘的性质与其致病潜能有关； 分子生物学与癌基因；生长因子及其作用机制 增殖；炎症机制；参与 活性氧物种等。演讲和讨论将 有助于我们理解颗粒物如何引起细胞 损伤、炎症和生长障碍，并将允许 肺的预防和治疗方法的发展 疾病。

Airborne fibers and particles are of significance to occupational and environmental health. Many of these pollutants cause respiratory disease including pulmonary fibrosis (asbestos, kaolin, silica, talc), bronchogenic carcinoma (asbestos, hematite) and mesothelioma (asbestos, erionite and other fibers of similar dimension to asbestos). Others are thought to act as carriers for chemical carcinogens in the atmosphere including polycyclic aromatic hydrocarbons in cigarette smoke. A number of particulates or 'nuisance dusts' (cotton, glass) also cause inflammatory changes which can contribute to dermatitis, asthma and chronic respiratory disease. The mechanisms by which mineral dusts cause cell damage and altered proliferation and/or differentiation of cells are unclear. The purpose of this meeting (to be held September 21-23, 1988 in Sherbrooke, Quebec, Canada), the fourth in a series of international workshops occurring approximately every 3-4 years, is to bring together approximately 125 eminent scientists performing "state-of-the-art" clinical and basic research on mechanisms of action of fibers and particulates on 'target' cells of disease. Sessions-in-depth will include: Physico-chemical properties of dusts as related to their pathogenic potential; Molecular biology and oncogenes; Growth factors and mechanisms of proliferation; Mechanisms of inflammation; Involvement of active oxygen species, etc. The presentations and discussion will contribute to our understanding of how particulates cause cell damage, inflammation, and disturbances in growth and will allow the development of preventive and therapeutic approaches to lung disease.