EFFICACY OF COCAINE TREATMENTS--A COLLABORATIVE STUDY

可卡因滥用在美国已达到流行病的程度。 States. 尽管问题的规模很大，但人们对 治疗的有效性。 本申请建议 确定两种流行形式的比较功效， 为有依赖性的人提供的住院和门诊治疗 并确定相对成本效益（CE） 和成本效益（CB）这两种治疗方法。 其他目标是 检验关于治疗结果的假设， 社会学习和社会支持理论， 研究样本的描述性数据。 样品将 由劳动力组成（蓝领到 专业人士）在私人非营利组织寻求治疗的人 部门 研究设计，回归不连续性，是一个 强有力的准实验替代随机 分配给治疗。 使用这种设计，受试者严重 可卡因依赖和相关的心理社会问题将是 分配至住院治疗组和严重程度较轻的受试者 受扶养人将被分配到门诊治疗。 科目 将在治疗入组时、治疗期间和12个月内进行评估 在退出治疗后的几个月。 两大类 将评估结果：药物使用，包括可卡因的使用， 酒精和其他药物;以及社会心理功能，包括 在就业、家庭和其他社会 关系和医疗保健。 大约600名男女 整个加州，从21-58岁，谁 参加可卡因住院或门诊治疗 依赖性将被招募到研究中。 本研究将 CALNET是一个广泛的网络， 基于医院的化学依赖康复服务， 为超过50%的县的居民提供护理， 加州。为了能够全面评价 治疗研究，这项研究将适用于经济 CE和CB方法治疗可卡因依赖。 这些经济评估分析将提供关键的 政策和治疗决策的信息。

Cocaine abuse has reached epidemic proportions in the United States. Despite the scale of the problem, little is known about effectiveness of treatments. This application proposes to determine the comparative efficacy of two prevalent forms of treatment, inpatient and outpatient, for persons with dependence on cocaine and also to determine relative cost-effectiveness (CE) and cost-benefits (CB) of these two treatments. Other goals are to test hypotheses regarding treatment outcomes derived from social learning and social support theories and to compile descriptive data of the sample under study. The sample will consist of persons who are in the work force (blue-collar to professionals) who seek treatment in the private non-profit sector. The research design , regression discontinuity, is a powerful quasi-experimental alternative to randomized assignment to treatments. Using this design, subjects with severe cocaine dependency and related psychosocial problems will be assigned to inpatient treatment and subjects with less severe dependency will be assigned to outpatient treatment. Subjects will be assessed at treatment entry, in-treatment, and for 12 months following exit from treatment. Two major categories of outcome will be assessed: drug use, including use of cocaine, alcohol and other drugs; and psychosocial functioning, including functioning in the areas of employment, family and other social relations, and health care. Approximately 600 men and women throughout the state of California, from 21-58 years of age, who enroll in inpatient or outpatient treatment for cocaine dependency will be recruited into the study. The study will be conducted at member programs of CALNET, an extensive network of hospital-based chemical dependency recovery services that provides care to residents of over 50% of the counties in California. To allow for comprehensive evaluation of the treatments to be studied, this research will apply economic CE and CB methods to the treatment of cocaine dependency. These economic appraisal analyses will provide critical information for policy and treatment decisions.