BEHAVIORAL CORRELATES OF HIPPOCAMPAL NEUROPLASTICITY

本研究的目的是评估学生的行为。 大鼠齿状回发芽的意义 单侧或双侧海马区损伤后的海马区结构 大鼠内嗅皮层(EC)。这些研究将集中在 扩散的同源输入(即， 交叉颞齿投影)对恢复的影响 与单侧EC损伤相关的空间交替缺陷。 将使用两个标准来评估萌芽是否 行为意义：1)神经再支配的时间进程 必须与行为恢复的时间进程同步。2) 对发芽纤维的系统处理必须产生一种 随之而来的行为变化。这项调查将雇用 实现所述目标的两种方法：a)困难 学习的交替任务的属性将变化以确定 在DG中萌发对行为有贡献的限度 恢复。B)EC的进行性病变，已知 加速DG萌发，将被用来确定是否 行为恢复的速度也加快了。空间 交替将被用作行为分析，因为之前 有证据表明，它对神经的再支配很敏感。 EC损坏后的DG。拟议的项目将提供 对一种潜在的 有助于中枢神经系统术后功能的恢复 受伤。

The purpose of this research is to evaluate the behavioral significance of sprouting in the dentate gyrus (DG) of the hippocampal formation after uni- or bilateral lesions of the entorhinal cortex (EC) in rats. These studies will focus on the contribution that a proliferated homologous input (i.e., the crossed temporodentate projection) makes to the recovery from spatial alternation deficits associated with unilateral EC damage. Two criteria will be used to assess whether the sprouting is behaviorally meaningful: 1) The time course of the reinnervation must parallel the time course of the behavioral recovery. 2) Systematic manipulation of the sprouted fibers must produce a concomitant change in behavior. This investigation will employ two approaches to attain the stated objective: A) The difficulty of a learned alternation task will be varied to determine the limits within which sprouting in the DG contributes to behavioral recovery. B) Progressive lesions of the EC, which are known to accelerate DG sprouting, will be used to determine whether the rate of behavioral recovery is also accelerated. Spatial alternation will be used as the behavioral assay because previous evidence has shown it to be sensitive to the reinnervation of the DG after EC damage. The proposed project will provide fundamental new insights into a mechanism which potentially contributes to recovery of function after central nervous system injury.