Factory in a Fumehood: Reagentless Flow Reactors as Enabling Techniques for Manufacture

这项提议旨在将来自学术界和工业界的一支独特的科学家团队聚集在一起，为高价值化学产品的无试剂合成开发新的使能制造技术。为什么是无人？在传统的化学过程中，一旦试剂完成了其任务，就需要将其从产品流中移除。除非用过的试剂可以重新激活，否则必须对废液进行处理。大多数过程需要大量试剂，这给制药等高价值产品的制造带来了沉重的财务和环境负担。圣杯将是完全避免使用试剂。光化学、电化学和热化学是无试剂技术，只需要电能作为主要投入，将是该项目的重点，以便为制造提供新的使能技术。通过使用流动化学技术，这三个领域可以连接在一起，提供快速获得复杂、高价值产品的途径--这被概念化为‘Fumehood中的工厂’--在这里，可以以较小的占地面积实现扩大规模，并大大减少运营成本和浪费。

This proposal aims to bring together a unique team of scientists from academia and industry to develop new enabling manufacturing techniques for the reagentless synthesis of high value chemical products. Why reagentless? In traditional chemical processes once a reagent has performed its task it needs to be removed from the product stream. Unless the spent reagent can be reactivated then the waste stream must be dealt with. Most processes require large amounts of reagent, placing a heavy financial and environmental burden on manufacturing of high value products such as pharmaceuticals. The Holy Grail would be to avoid reagents altogether. Photochemisty, electrochemistry and thermochemistry are reagentless techniques, requiring only electrical energy as a primary input and will be the focus of this project in order to provide new enabling techniques for manufacturing. By the use of flow chemistry techniques these three areas can be connected together to provide rapid access to complex, high value products - this is conceptualized as a 'Factory in a Fumehood' - where scale-up can be achieved with a small footprint and with greatly reduced operating costs and waste.