A 500MHz 13C-cryoprobe and NMR Spectrometer @ Bristol

核磁共振（NMR）光谱是分子结构分析中信息最丰富的工具，使科学家能够探测分子中单个原子的环境。碳原子（特别是其原子核）的NMR分析是最理想的技术，因为碳在英国研究中心研究的绝大多数尖端化合物中无处不在-从塑料和聚合物，到洗涤剂，石化产品到现代制药和有机电子产品。不幸的是，碳的核磁共振遇到了一个严重的挑战-它是令人难以置信的不敏感，主要是由于核磁共振活性碳-13（13 C）核的丰度非常低。该项目将在布里斯托大学现有的大型核磁共振设施中安装一个尖端的13 C敏感核磁共振低温探针，该设施为数百名研究人员提供服务，研究广泛的科学问题，从操纵生物体中的生物合成过程，超高效的化学催化，以控制纳米结构的发展与纳米科学的应用。这种低温NMR探头中的超导线圈将检测弱13 C NMR信号的灵敏度提高了约10倍，超过了绝大多数NMR设施（包括布里斯托的）中使用的最现代化的室温探头。这种13 C-冷冻探针的灵敏度将填补布里斯托核磁共振设施目前能力的实质性空白，使一套不切实际的核磁共振技术能够应用于这一广泛的科学问题-特别是使实验速度提高100倍（数据收集时间为分钟或小时，而不是几天甚至几周）。将13 C冷冻探针纳入布里斯托大学NMR设施将创建一个英国领先的NMR中心，该中心将与世界上任何地方的最佳实验室竞争这些研究。该仪器将与现有的9台其他液体NMR仪器（夏末将有11台）一起集成到目前的UoB NMR设施中，并将得到一个支持人员专家团队的支持，他们在支持主要的多项目，多用户NMR仪器方面拥有超过50年的经验。正是这种尖端技术、高效的UoB NMR设备和相关研究环境的结合，将确保高效利用这一设备投资，并确保科学家依靠这一关键硬件的能力获得最佳结果。

Nuclear Magnetic Resonance (NMR) Spectroscopy is the most information-rich tool for molecular structure analysis, allowing scientists to probe the environment of individual atoms in molecules. The NMR analysis of carbon atoms (specifically their nuclei) is, in turn, the most desirable technique as carbon is ubiquitous in the vast majority of cutting-edge chemical compounds being studied in UK research centres - from plastics and polymers, through detergents, petrochemicals to modern pharmaceuticals and organic electronics. Unfortunately, NMR of carbon suffers from a serious challenge - it is incredibly insensitive, primarily due to the very low-abundance of the NMR-active carbon-13 (13C) nucleus.This project will install a cutting-edge 13C-sensitive NMR cryogenic probe into the existing large-scale University of Bristol NMR Facility, which serves hundreds of researchers studying a wide range of scientific problems, from manipulation of biosynthetic processes in organisms, ultra-efficient chemical catalysis to the development of controlled nano-architectures with applications in nanoscience. The superconducting coils in this cryogenic NMR probe increase the sensitivity for detection of weak 13C NMR signals by around 10-fold over the most modern room temperature probes used in the vast majority of NMR facilities (including Bristol's). The sensitivity of this 13C-cryoprobe will fill a substantial void in current capabilities of the Bristol NMR Facility, enabling a suite of otherwise impractical NMR techniques to be applied to this broad spectrum of scientific problems - in particular making experiments up to 100-times faster (so minutes or hours for data collection, rather than days or even weeks). The incorporation of a 13C-cryoprobe into the University of Bristol NMR Facility will create a UK-leading NMR centre that will compete with the best laboratories for these studies anywhere in the world. This instrument will be integrated into the current UoB NMR Facility, alongside the existing suite of 9 other liquids NMR instruments (11 by late summer) and will be supported by an expert team of support staff who between them have over 5 decades of experience in supporting major multi-project, multi-user NMR instrumentation. It is this combination of cutting-edge technology, a highly efficient UoB NMR Facility and the associated research environment that will ensure a highly effective use of this equipment investment, and ensure optimal results for the scientists relying on the capabilities of this critical hardware.