Manufacturing Green Nanoparticles for Efficient Cell Manufacture

材料-细胞界面强烈依赖于表面和材料属性，可以促进细胞生长，在实现对细胞制造的精细控制方面非常有用。我们将解决与电池生产过程的总效率相关的挑战，从受自然启发的定制绿色纳米材料(GN)的制造开始，对这些纳米颗粒进行表征，并评估这些材料对后续电池制造的影响。作为这一呼吁的一部分，我们寻求为期2年的有限概念验证资金。为了制造绿色纳米材料以有效地制造电池，存在以下挑战：-我们能否扩大绿色纳米材料制造以提高竞争力？-我们如何控制流程以控制制造？-我们能否展示绿色二氧化硅在电池制造中的应用？-哪些纳米级特性使绿色二氧化硅具有优势？我们将通过跨纳米材料化学、流体动力学、细胞制造和纳米技术等非传统学科的合作，并结合两个EPSRC创新制造中心和两个EPSRC制造研究员的专业知识，从独特的角度应对这些挑战。我们已经证明，GN提供了一种环境友好的方法，是可扩展的，具有很好的生物医学应用前景，同时确立了在纳米材料放大操作中混合的重要性。我们还确定了高效和自动化电池制造的策略，并开发了纳米探针来广泛研究纳米级的表面和界面。在这个项目中，我们的目标是在这一成功的基础上再接再厉，解决一些关键挑战，实现适合于细胞制造的绿色纳米材料的大规模制造。

Material-cell interface, which strongly depends on surface and materials properties, can augment cell growth and is extremely useful in enabling exquisite control of cellular manufacturing. We will address challenges related to the total efficiency of the cell production process starting with nature-inspired manufacture of bespoke green nanomaterials (GN), characterizing these nanoparticles, and evaluating how these materials affect the subsequent cell manufacture. As part of this call, we seek limited proof-of-concept funding 2 years. In order to manufacture green nanomaterials for efficient cell manufacture, there are following challenges:- Can we scale up green nanomaterial manufacture so as to be competitive?- How can we control flow to control manufacturing?- Can we showcase the application of green silicas for cell manufacture?- What nanoscale properties make green silicas superior?We will address these challenges from a unique perspective by collaborating across non-traditional disciplines involving nanomaterials chemistry, fluid dynamics, cell manufacturing and nanotechnology, and combining expertise from two EPSRC Centres for Innovative Manufacturing and two EPSRC Manufacturing Fellows. We have shown that GN, which provide an environmentally friendly approach, are scalable and have promising biomedical applications, while establishing the importance of mixing in nanomaterials scale-up operations. We have also identified strategies to efficient and automated cell manufacturing and developed nano-probes to extensively investigate surfaces and interfaces at the nanoscale. In this project, we aim to build on this success and go significantly beyond to address a number of key challenges to deliver large scale manufacturing of green nanomaterials suitable for cellular manufacture.