Core Capability for Chemistry Research at the University of Warwick

该提案的主要目的是通过购置新设备来提高华威大学化学系的研究能力。我们将增加基质辅助激光解吸电离（MALDI）质谱分析和核磁共振（NMR）光谱分析的增强能力。这将对该部60%的工作人员和研究人员产生重大的有益影响，因为其能力（即可以运行更多的样本）和能力（即通过提高分辨率获得更好的数据）都将显著增加。该设备将增强EPSRC优先领域的广泛研究活动，具体如下：(i)化学生物学，其中拟议的仪器将促进许多项目，包括基因组学驱动的天然产物发现和各种药物化学项目，包括金属基前药的开发。它也将巩固对合成生物学的兴趣。（ii）合成和催化——EPSRC优先研究领域包括过渡金属催化、有机催化和生物催化。各种其他合成化学项目将得到加强，包括那些与EPSRC重大挑战有关的项目，Dial-a-Molecule。（iii）高分子化学——许多不同的专业将受益，包括那些专注于蛋白质偶联到聚合物、糖共聚物、生物材料、药物输送和纳米反应器的专业。（iv）分析科学-灵敏度的提高将加强许多项目，包括金属蛋白和膜蛋白的生物物理研究。重要的是，新的能力也将帮助我们进一步加强与工业和相关商业部门的接触和合作。

The main objective of this proposal is to enhance the research capabilities of the Department of Chemistry at the University of Warwick, through the acquisition of new equipment. We will add enhanced capabilities in matrix assisted laser desorption ionisation (MALDI) mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. These will have major beneficial impacts on >60% of staff and researchers in the Department through significant increases in both capacity (i.e. more samples can be run) and capability (i.e. better data through improved resolution). This equipment will enhance a wide range of research activities in EPSRC priority areas as detailed below:(i) Chemical Biology, where the proposed instruments will facilitate many programmes including genomics-driven natural product discovery and various medicinal chemistry programmes including the development of metal based pro-drugs. It will also underpin interests in Synthetic Biology. (ii) Synthesis and Catalysis - work in this EPSRC priority area includes work on transition metal catalysis, organocatalysis and biocatalysis. A variety of other synthetic chemistry programmes will be enhanced including those relevant to the EPSRC grand challenge, Dial-a-Molecule. (iii) Polymer Chemistry - many varied programmes will benefit including those focused on protein conjugation to polymers, glycopolymers, biomaterials, drug delivery and nanoreactors.(iv) Analytical Science - The increased sensitivity will enhance many projects including biophysical investigations of metalloproteins and membrane proteins. Importantly, the new capabilities will also help us further strengthen our engagement and collaboration with industry and relevant business sectors.