Chronic Myeloid Leukaemia: Changing the treatment paradigm

大多数慢性粒细胞白血病患者对治疗有很好的反应，但需要终身治疗。我们开创了一些患者可以停止治疗而不会复发的概念（免治疗缓解-TFR）。通过研究免疫系统和白血病干细胞，我们将确定为什么TFR对某些患者是可能的，但不是所有患者。这是提高TFR率的关键，从而将CML的目标从疾病控制转向治愈。

Most patients with chronic myeloid leukaemia achieve excellent responses to therapy but need therapy for life. We have pioneered the concept that some patients can cease their therapy and not relapse (treatment free remission –TFR). By studying the immune system and the leukaemic stem cells we will determine why TFR is possible for some, but not all patients. This holds the key to improving the rate of TFR, thus moving the CML goal from disease control to cure.