Circuit Breaker: Investigating the regulatory circuits controlling expression of drug efflux pumps in the nosocomial pathogen Acinetobacter baumannii

由耐药致病菌引起的医院获得性感染花费了数十亿美元，并增加了患者的痛苦和发病率。本研究将研究一种主要的医院获得性细菌病原体鲍曼不动杆菌多药外排泵的控制基因。这些外排泵通过将抗菌剂泵出细胞，使细菌对抗菌剂产生耐药性。这些结果将使我们能够更好地追踪耐药菌株，并为治疗方案提供信息。

Hospital-acquired infections caused by drug resistant pathogenic bacteria cost billions of dollars and increase patient pain and morbidity. This research will study the genes controlling multidrug efflux pumps in a major hospital-acquired bacterial pathogen, Acinetobacter baumannii. These efflux pumps make the bacteria resistant to antimicrobials by pumping them out of the cell. The results will allow us to better track drug resistant strains and will inform treatment options.