HIV INFECTION--HOST FACTORS IN ACUTE PERIODONTAL DISEASE

以前对急性坏死性溃疡性牙周炎(ANUG)的研究有 与白细胞功能障碍相关的疾病活动(PMN和 淋巴细胞)。最近，Anug和Anug样感染已经 报告了感染人类免疫缺陷病毒(HIV)的患者。 HIV感染的牙周临床特征可以跨越 无症状到肿瘤的机会性感染。目前，最多的 准确预测HIV感染中免疫功能障碍的严重程度 似乎是循环中CD4T淋巴细胞的绝对数。 这项研究的具体目的是： 1.研究HIV血清阴性患者牙周微生物区系的特征。 血清阳性的ANUG患者 2.评估淋巴细胞亚群及其功能。 群组 3.评估同一组中的白细胞和差异图谱 这项研究在ANUG或ANUG样皮损的患者中将调查 HIV-血清状况、牙周微生物区系、WBC计数和差异，以及 淋巴细胞亚群(CD4/CD8)及其功能。牙周 微生物区系将通过培养和显微方法进行表征。这个 淋巴细胞功能测试将测量淋巴细胞的激活和 从外周血分离的T细胞产生白细胞介素2。这个 上述参数还将分成以下几组进行检查： 1.HIV血清阴性与牙周健康；2.HIV血清阳性与牙周健康 牙周健康；3.HIV血清阳性，中重度牙周炎； HIV(高危)血清与牙周健康呈阴性。 牙周炎或严重疼痛的牙周炎可能是常见的早期临床症状。 并可作为未来发展的预测指标。 艾滋病。HIV临床或实验室标志物的进一步阐明 感染和发展艾滋病的前驱体将有益于 患者、公共卫生官员和护理提供者在治疗的时机上， 预防艾滋病毒传播，并设计临床试验。

Previous studies of acute necrotizing ulcerative gingivitis (ANUG) have associated disease activity with leukocyte dysfunction (PMN and lymphocyte). More recently, ANUG and ANUG-like infections have been reported in patients infected with the human immunodeficiency virus (HIV). The periodontal clinical features of HIV infection can span from asymptomatic to opportunistic infections to neoplasia. Presently, the most accurate predictor of the severity of immune dysfunction in HIV infection appears to be the absolute number of circulating CD4 T lymphocytes. The specific aims of this study are: 1. to characterize the periodontal microflora from HIV-seronegative and seropositive ANUG patients 2. to assess lymphocyte subpopulations and their function in this same group 3. to assess WBC and differential profiles in this same group This study in patients with ANUG or ANUG-like lesions will investigate the HIV-serostatus, periodontal microflora, WBC counts and differentials, and lymphocyte subpopulations (CD4/CD8) and their function. The periodontal microflora will be characterized by cultural and microscopic methods. The lymphocyte function tests will measure lymphocyte activation and interleukin-2 production in T cells isolated from peripheral blood. The aforementioned parameters will also be examined in the following groups: 1. HIV-sero- negative with periodontal health; 2. HIV serropositive with periodontal health; 3. HIV-seropositive, moderate-severe periodontitis; 4. HIV(high risk) seronegative with periodontal health. ANUG or a severe painful gingivitis may be a frequent early clinical sign of HIV infection and may serve as a predictor for future development of AIDS. Further elucidation of clinical or laboratory markers of HIV infection and of preactors for the development of AIDS will benefit the patient, public health officials, and care providers in timing of therapy, prevention of HIV transmission, and design of clinical trials.