PHYSIOLOGY-ADRENERGIC INFLUENCE ON RENAL FLUID TRANSFER

虽然肾上腺素能神经系统的重要调节作用， 多年来，人们一直怀疑肾功能系统， 只是在过去的几年里， 该系统已在实验中得到充分证明， 调节肾小球和肾小管的盐和液体转移 程度. 在这份为期5年的研究项目提案中，PI将 重点在于阐明 溶质和流体模式的一些令人困惑的现象 在急性ECF容量耗竭的动物模型中观察到， 充血性心力衰竭 而这两个条件， 其特点是看似相似的系统环境， 特别是增强肾上腺素能神经活动，近端盐 和水的重吸收似乎只在动物中增强 充血性心力衰竭 在拟议的项目中，PI 旨在描述近端小管转运的细节， 在这两种情况下的制度，并寻求确定的作用， 该运输系统中的肾上腺素能神经。 此外，委员会认为， 将尝试测试假设的可能性， 肾上腺素能系统激活的慢性性解释了 观测到的传输模式， 机制等 由于近端小管重吸收盐和水 包括跨上皮和跨毛细血管转移 物质，实验方法包括研究这两个 这些过程。

Although an important regulatory role of the adrenergic nervous system in renal function has been suspected for many years, it is only in the past several years that the functional significance of this system has been fully demonstrated experimentally in the regulation of salt and fluid transfer at the glomerular and tubular levels. In this proposal of 5-year research projects, the PI will focus on elucidating the physiological mechanisms which underlie the somewhat puzzling phenomena for solute and fluid patterns observed in animal models of acute ECF volume depletion and congestive heart failure. Whereas these two conditions are characterized by a seemingly similar systemic milieu, particularly, enhanced adrenergic nerve activity, proximal salt and water reabsorption appear to be enhanced only in animals with congestive heart failure. In the proposed projects, the PI intends to characterize the details of proximal tubule transport system in these two cnditions and seek to ascertain the role of the adrenergic nerves in this transport system. Furthermore, attempts will be made to test the hypothetical possibility that the chronicity of activation of the adrenergic system accounts for the observed transport patterns by affecting the underlying mechanisms. Since proximal tubule reabsorption of salt and water involves both transepithelial and transcapillary transfer of substances, the experimental approach includes studies of both of these processes.