SOCIAL CONFLICT: IMMUNOLOGICAL & ENDOCRINOLOGICAL CONSEQ

最近，“应激”在免疫调节中的作用已被发现。 正在接受深入调查 然而，“压力”是一个高度 模糊的术语和许多的压力操纵， 实验室很少或根本不受应力影响， 自然 这项研究应用采取了新颖的方法， 使用由激动剂引起的生物学相关应激， 在一个社交网络中， 冲突范式，以了解机制， 控制应力诱导的调制的相互关系 免疫系统 免疫学实验的结果将形成 选择实验组的依据 内分泌分析，以确定可能重要的 免疫的内分泌调节途径。 免疫应答将通过体内 以及特异性和非特异性免疫刺激剂的体外使用， 流式细胞仪细胞分析和免疫调节的测量 分子。 内分泌分析将包括选择性 通过手术、药理学和 免疫中和技术。 根据从以下方面获得的结果： 以上，实验将被设计为专门测试 免疫系统和内分泌系统相互作用的程度 以应对社会冲突的压力。 本研究设计 因此，将允许直接的因果关系， 免疫系统和内分泌系统需要检查。 因此，这 一项提案试图解决生物学相关压力是否 可以调节免疫能力。 该信息可以 因此适用于获得性免疫缺陷的研究 综合征（艾滋病），因为它已被建议， 艾滋病的发生可能部分取决于 内分泌和免疫系统的心理影响 受害者所经历的压力。

The role of "stress" in the modulation of immunity has recently come under intensive investigation. However, "stress" is a highly ambiguous term and many of the stress manipulations in the laboratory bear little or no relation to stress as encountered in nature. This research application takes the novel approach of using the biologically relevant stress resulting from agonistic encounters and aggressive interactions between mice in a social conflict paradigm to gain an understanding of the mechanisms and interrelationships governing stress induced modulation of the immune system. Results from immunological experiments will form the basis for selection of experimental groups to be used for endocrinological analysis in order to identify presumably important pathways of endocrine mediation of immunity. Immunological responsiveness will be assessed through the in vivo and in vitro use of specific and non-specific immune stimulants, flow cytometer cell analysis and measurement of immunoregulatory molecules. Endocrinological analysis will include selective ablation of endocrine function by surgical, pharmacological and immunoneutralization techniques. Based on results obtained from the above, experiments will be designed to specifically test the degree to which immunological and endocrinological systems interact in response to the stress of social conflict. This research design will thus allow for a direct cause and effect relationship between the immune and endocrine systems to be examined. As such, this proposal seeks to address whether a biologically relevant stress can modulate immunological competence. This information may therefore be applicable to the study of Acquired Immune Deficiency Syndrome (AIDS), since it has been suggested that the progression of AIDS may be dependent, in part, on altered interactions between the endocrine and immune systems resulting from the psychological stress that is experienced by its victims.