STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES

计划中的研究将是正在进行的项目的继续，以反映 对人类正常和异常生长调节的长期兴趣 造血系统。具体项目包括： 1)造血肿瘤的细胞遗传学和分子遗传学研究。 慢性B细胞和T细胞肿瘤的长期染色体研究 以确定其诊断和预后价值，并 为正在进行的合作提供材料，与卡洛·克罗齐博士，on 参与这些疾病发病机制的特定癌基因和 基因调控改变的机制。 2)继续成人染色体异常的相关研究 和儿童非淋巴细胞白血病前期，包括血液性疾病 与非典型染色体脆性综合征有关。这些研究 也将延伸到分子水平，对基因进行批判性的研究 与某些非淋巴细胞白血病前期和白血病有关。 3)另外一组关于生长调控的持续相关研究 在正常淋巴细胞中，重点关注白细胞介素1、白介素2在 “触发”正常的人类T细胞。各种刺激物和 T细胞增殖抑制剂将用于进一步研究 涉及的生物途径和特定基因的相关表达 原癌基因。

The planned studies will be a continuation of ongoing projects that reflect a long interests in normal and abnormal growth regulation in the human hematopoietic system. The specific projects include: 1) Cytogenetic and molecular genetic studies in hematopoietic neoplasia. Long-term chromosome studies of the chronic B cell and T cell neoplasms will be extended, to determine their diagnostic and prognostic value and to provide material for ongoing colloborations, with Dr. Carlo Croce, on specific oncogenes involved in the pathogenesis of these disorders and mechanisms of altered gene regulation. 2) Continuation of related studies on chromosomal abnormalities in adult and childhood nonlymphocytic preleukemia, including hemic disorders associated with atypical chromosomal fragility syndromes. These studies will also extend to the molecular level, investigationg genes critically involved in certain nonlymphocytic preleukemias and leukemias. 3) An Additional group of continuing related studies of growth regulation in normal lymphocytes, focusing on the role of interleukins (IL1, IL2) in the "triggering" of normal human T cells. Various stimulators and inhibitors of T cell proliferation will be used to investigate further the biological pathways involved and related expression of specific genes and proto-oncogens.