CHEMISTRY AND BIOLOGY OF HUMAN LYMPHOCYTES

该申请提出了在各种领域的研究， 人类淋巴细胞的化学和生物学。 的问题 研究涉及免疫识别的分子基础， 以及控制和调节人类增殖的因素 淋巴细胞 所采用的技术包括蛋白质 化学和晶体学，分子遗传学，免疫学和 病毒学 具体的研究领域是1）蛋白质化学 和免疫识别分子的晶体学，2） I类和II类MHC结构与功能的关系 分子，3）克隆人主要组织相容性复合体， 特别是肿瘤坏死因子基因在其中的位置， 4)人II类抗原的表达，5）调节 人类II类MHC基因转录，6）T细胞 受体的作用，特别是TCR γ δ受体在 免疫监视，7）爱泼斯坦-巴尔病毒，特别是 诱导细胞增殖的病毒功能的性质，8） 4F 2蛋白在细胞增殖中的作用。

This application proposes studies in a variety of areas relating to the chemistry and biology of human lymphocytes. The problems being studied involve the molecular basis of immune recognition as well as factors which govern and regulate proliferation of human lymphocytes. The techniques being employed include protein chemistry and crystallography, molecular genetics, immunology and virology. Specific areas of investigation are 1) protein chemistry and crystallography of immune recognition molecules, 2) relationship of structure to function in class I and class II MHC molecules, 3) cloning the human major histocompatibility complex, especially the location of tumor necrosis factor genes within it, 4) expression of human class II antigens, 5) regulation of transcription of human class II MHC genes, 6) studies of T cell receptors particularly the role of the TCR gamma delta receptor in immunosurveillance, 7) the Epstein-Barr Virus particularly the nature of the viral functions which induce cell proliferations, 8) the role of the 4F2 protein in cell proliferation.