OPTIMIZATION OF A RESPONSIVE CLINICAL PERFUSION MONITOR

该项目的目标是开发一种敏感的、线性的、微创的 热敏传感器作为临床仪器的基础 测量和监测组织热特性，包括 灌流。组织血流量是人体最重要的生理功能之一 参数也是最难测量的参数之一。通过审阅 过去关于热探头/组织相互作用的工作提出了一种设计 其性能以优化传感器为基础的仪器 对组织属性的反应。结果表明，该换能器可以是 设计成对组织导热系数具有线性响应，并且 灌流，极大地简化了必要的分析程序和 仪器仪表。第一阶段项目将涉及设计、制造 并在体外实验中对该换能器进行了评估。

This project's goal is to develop a sensitive, linear, minimally invasive thermal transducer as the basis of a clinical instrument for the measurement and monitoring of tissue thermal properties, including perfusion. Tissue blood flow is one of the most important physiologic parameters and also one of the most difficult to measure. By reviewing past work on thermal probe/tissue interactions a design is proposed for an instrument whose performance is based upon optimizing the transducer response to tissue properties. It is shown that the transducer may be designed to possess a linear response to tissue thermal conductivity and perfusion, enormously simplifying the necessary analysis procedure and instrumentation. The Phase I project will address the design, fabrication and evaluation of this transducer in in vitro experiments.