EXERCISE USING 31P NMR AND AN ISOKINETIC ERGOMETER

基于宾夕法尼亚大学对一项 磷能量公司(P-E)核磁共振谱仪，用于验证31P 在疾病和正常的人体组织中，P-E已经发展出一种组合 核磁共振/功输出测量仪。这项研究已经在 受试者患有外周血管疾病，遗传缺陷， 心肌病以及正常志愿者和运动员导致的一项数据 各种磷酸盐的比例，例如， 磷酸肌酸/无机磷(PCr/PI)、磷酸二酯/PI，以及 糖磷酸盐/PI等可用于确定组织的状态。 有人建议将这项工作扩展到“表观”常态的研究 年龄在65岁到75岁之间的志愿者试图将现有的 与锻炼方案相关的持续测量数据，以及 营养协议。为了做到这一点，有必要发展 一种适用于磁力腿部运动的新型无磁力连杆机构。它是 预计31P核磁共振、非磁链和测功器相结合 可能成为一种重要的商业筛选测试，以确定 早期PVD或糖尿病；2)评估运动的效果和 老年人群运动与营养的关系

Based on research performed at the University of Pennsylvania on a Phospho-Energetics, Inc. (P-E) NMR spectrometer for the "Validation of 31p in Diseased and Normal Human Tissues", P-E has developed a combination NMR/work output measuring instrument. Studies have been performed with subjects suffering from peripheral vascular disease, genetic defects, cardiomyopathy as well as normal volunteers and athletes leading to a data base from which the ratios of various phosphates, e.g., phosphocreatine/inorganic phosphate (PCr/Pi), phospho diesters/Pi, and sugar phosphates/Pi etc. may be used to determine the state of tissue. It is proposed to extend this work into a study of "apparent" normal volunteers between the ages of 65 and 75 to try and correlate the existing data with ongoing measurements relative to an exercise protocol and nutritional protocol. In order to do this, it will be necessary to develop a new non magnetic linkage suitable for in magnet leg exercise. It is expected that the combined 31P NMR, non magnetic linkage and ergometer could become commercially important as a screening test to 1) identify incipient PVD or diabetes and 2) to evaluate the effect of exercise and the relationship between exercise and nutrition in the aging population.