IMMUNOSENSOR FOR DRUG MONITORING

对于滥用药物的有效筛选，简单但毫不含糊 需要可在现场进行的分析方法。这 该项目旨在开发一种用于检测药物的免疫传感器 滥用职权。虽然可行性研究将用可卡因进行 及其主要代谢物苯甲酰ecGonine，该传感器可适用于 可获得抗体的物质，包括治疗药物 以及其他具有生理活性的化合物。免疫传感器的操作 不需要与免疫分析相关的常规程序，例如 移液、加入试剂、手动分离、混合等，但 只需将一次性传感器浸入生物介质(尿液， 血、唾液)。生成的信号将通过现有的 用于测量血糖的技术。最短的时间 完成化验的时间估计在3到5分钟之间 无需停止反应即可完成。

For the efficient screening of drugs of abuse, simple but unambiguous analytical methods are required which can be performed on-site. This project is designed to develop an immunosensor for the detection of drugs of abuse. While the feasibility studies will be performed with cocaine and its major metabolite, benzoylecgonine, the sensor can be adapted to substances for which antibodies are available, including therapeutic drugs and other physiologically active compounds. Operation of the immunosensor does not require the usual procedures associated with immunoassays such as pipetting, adding to reagents, manual separation, mixing and the like but just dipping the disposable sensor into the biological medium (urine, blood, saliva). The generated signal will be monitored with existing technology as used for the measurement of blood glucose. The minimal time period for completing the assay is estimated to be between 3 and 5 minutes without the requirement to stop a reaction for completion.